The STING controlled cytosolic-DNA activated innate immune pathway and microbial disease

Hiroyasu Konno, Glen N. Barber

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

The innate immune system is critically important for the primary sensing of invading pathogens. Over the past decade, the cellular sensors important for recognizing microbial entry into the host cell have been largely elucidated. These sensors, some of which are evolutionarily conserved, include the Toll-like receptor (TLR) and RIG-I-like helicase family (RLH) pathway that can recognize bacterial and viral non-self nucleic acid. In addition, a cellular sensor referred to as STING (for stimulator of interferon genes) has been shown to be critical for triggering host defense countermeasures, including stimulation of the adaptive immune response, following the detection of cytosolic DNA species. The STING pathway has now been shown to be critical for activating innate immune gene transcription in response to infection by DNA pathogens such as herpes simplex virus 1 (HSV1) as well as retroviruses. In addition, it is clear that chronic STING activation can also cause autoinflammatory disease manifested by self-DNA. Here we review recent developments in our understanding of STING function, including importance in the control of microbial disease.

Original languageEnglish (US)
Pages (from-to)998-1001
Number of pages4
JournalMicrobes and Infection
Volume16
Issue number12
DOIs
StatePublished - Dec 1 2014

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Keywords

  • DNA sensor
  • Host defense
  • Interferon
  • STING

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Infectious Diseases

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