The stepwise activation of cytotoxic T lymphocytes

Gianni Gromo, Luca A Inverardi, Robin L. Geller, Barbara J. Alter, Fritz H. Bach

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The recognition of antigen is the first stage of T-lymphocyte maturation in vivo. Monoclonal antibodies directed against the T-cell receptor/CD3 complex and against other surface antigens can also provide this stimulus. Gianni Gromo and his colleagues are attempting to characterize the steps leading from this initial activation to full functional maturation. They suggest that while numerous pathways of activation exist, the particular pathway followed and to what extent activation occurs depend on both the stimulating ligand and its cell surface receptor.

Original languageEnglish
Pages (from-to)261-264
Number of pages4
JournalImmunology Today
Volume8
Issue number9
DOIs
StatePublished - Jan 1 1987
Externally publishedYes

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CD3 Antigens
Cell Surface Receptors
Cytotoxic T-Lymphocytes
Surface Antigens
T-Cell Antigen Receptor
Monoclonal Antibodies
Ligands
T-Lymphocytes
Antigens

ASJC Scopus subject areas

  • Immunology

Cite this

Gromo, G., Inverardi, L. A., Geller, R. L., Alter, B. J., & Bach, F. H. (1987). The stepwise activation of cytotoxic T lymphocytes. Immunology Today, 8(9), 261-264. https://doi.org/10.1016/0167-5699(87)90184-8

The stepwise activation of cytotoxic T lymphocytes. / Gromo, Gianni; Inverardi, Luca A; Geller, Robin L.; Alter, Barbara J.; Bach, Fritz H.

In: Immunology Today, Vol. 8, No. 9, 01.01.1987, p. 261-264.

Research output: Contribution to journalArticle

Gromo, G, Inverardi, LA, Geller, RL, Alter, BJ & Bach, FH 1987, 'The stepwise activation of cytotoxic T lymphocytes', Immunology Today, vol. 8, no. 9, pp. 261-264. https://doi.org/10.1016/0167-5699(87)90184-8
Gromo G, Inverardi LA, Geller RL, Alter BJ, Bach FH. The stepwise activation of cytotoxic T lymphocytes. Immunology Today. 1987 Jan 1;8(9):261-264. https://doi.org/10.1016/0167-5699(87)90184-8
Gromo, Gianni ; Inverardi, Luca A ; Geller, Robin L. ; Alter, Barbara J. ; Bach, Fritz H. / The stepwise activation of cytotoxic T lymphocytes. In: Immunology Today. 1987 ; Vol. 8, No. 9. pp. 261-264.
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