The status of the corticotropin releasing factor (CRF)

Murray Saffran, A. V. Schally

Research output: Contribution to journalArticlepeer-review

37 Scopus citations


Early in the history of studies on the release of ACTH by stress there were indications that ACTH might be released by multiple factors. But the neurohumoral theory, as formulated by G.W. Harris, suggested that every hypophysial hormone had its unique hypothalamic controlling agent and a search for the unique ACTH-releasing hormone went on for about 20 years. This review reexamines the case for multiple releasers of ACTH.

Original languageEnglish (US)
Pages (from-to)359-375
Number of pages17
Issue number5-6
StatePublished - 1977
Externally publishedYes


  • ACTH-Release
  • Adrenal cortex
  • Anterior pituitary
  • CRF
  • Hypothalamus
  • Stress
  • Vasopressin

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Endocrine and Autonomic Systems
  • Cellular and Molecular Neuroscience


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