The spectrum of liver disease in the acquired immunodeficiency syndrome

Stuart C. Gordon, K. Rajender Reddy, Edwin E. Gould, Robert McFadden, Christopher O'Brien, Maria De Medina, Lennox J. Jeffers, Eugene R. Schiff

Research output: Contribution to journalArticlepeer-review

72 Scopus citations


Abnormal liver chemistries, unexplained fevers, or hepatomegaly prompted 36 liver biopsies on 34 patients with the acquired immunodeficiency syndrome. The most common finding was the presence of hepatic granulomas, seen in 13 of the biopsy specimens. Eight of these granulomas were ill-defined, and 5 were more clearly associated with mycobacterial disease. Portal fibrosis and fatty infiltration were common, but a paucity of significant inflammatory activity was seen despite elevated aspartate aminotransferase levels, perhaps related to the underlying immunoincompetent status. Other noteworthy histopathologic findings included 1 patient each with peliosis hepatis and cryptococcal hepatitis. Electron-microscopic evidence of cytoplasmic tubular structures or viral particles were seen within the hepatocytes of 2 patients. It is concluded that a broad spectrum of hepatic histopathology may be seen in the acquired immunodeficiency syndrome, and that liver biopsy may be diagnostically valuable in the clinical investigation of such patients.

Original languageEnglish (US)
Pages (from-to)475-484
Number of pages10
JournalJournal of Hepatology
Issue number3
StatePublished - 1986

ASJC Scopus subject areas

  • Hepatology


Dive into the research topics of 'The spectrum of liver disease in the acquired immunodeficiency syndrome'. Together they form a unique fingerprint.

Cite this