The spectrum of liver disease in the acquired immunodeficiency syndrome

Stuart C. Gordon, K. Rajender Reddy, Edwin E. Gould, Robert McFadden, Christopher B O'Brien, Maria De Medina, Lennox J Jeffers, Eugene R Schiff

Research output: Contribution to journalArticle

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Abstract

Abnormal liver chemistries, unexplained fevers, or hepatomegaly prompted 36 liver biopsies on 34 patients with the acquired immunodeficiency syndrome. The most common finding was the presence of hepatic granulomas, seen in 13 of the biopsy specimens. Eight of these granulomas were ill-defined, and 5 were more clearly associated with mycobacterial disease. Portal fibrosis and fatty infiltration were common, but a paucity of significant inflammatory activity was seen despite elevated aspartate aminotransferase levels, perhaps related to the underlying immunoincompetent status. Other noteworthy histopathologic findings included 1 patient each with peliosis hepatis and cryptococcal hepatitis. Electron-microscopic evidence of cytoplasmic tubular structures or viral particles were seen within the hepatocytes of 2 patients. It is concluded that a broad spectrum of hepatic histopathology may be seen in the acquired immunodeficiency syndrome, and that liver biopsy may be diagnostically valuable in the clinical investigation of such patients.

Original languageEnglish
Pages (from-to)475-484
Number of pages10
JournalJournal of Hepatology
Volume2
Issue number3
DOIs
StatePublished - Jan 1 1986

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Liver Diseases
Acquired Immunodeficiency Syndrome
Liver
Granuloma
Biopsy
Peliosis Hepatis
Cytoplasmic Structures
Hepatomegaly
Aspartate Aminotransferases
Virion
Hepatitis
Hepatocytes
Fibrosis
Fever
Electrons

ASJC Scopus subject areas

  • Gastroenterology

Cite this

The spectrum of liver disease in the acquired immunodeficiency syndrome. / Gordon, Stuart C.; Rajender Reddy, K.; Gould, Edwin E.; McFadden, Robert; O'Brien, Christopher B; De Medina, Maria; Jeffers, Lennox J; Schiff, Eugene R.

In: Journal of Hepatology, Vol. 2, No. 3, 01.01.1986, p. 475-484.

Research output: Contribution to journalArticle

Gordon, SC, Rajender Reddy, K, Gould, EE, McFadden, R, O'Brien, CB, De Medina, M, Jeffers, LJ & Schiff, ER 1986, 'The spectrum of liver disease in the acquired immunodeficiency syndrome', Journal of Hepatology, vol. 2, no. 3, pp. 475-484. https://doi.org/10.1016/S0168-8278(86)80059-9
Gordon, Stuart C. ; Rajender Reddy, K. ; Gould, Edwin E. ; McFadden, Robert ; O'Brien, Christopher B ; De Medina, Maria ; Jeffers, Lennox J ; Schiff, Eugene R. / The spectrum of liver disease in the acquired immunodeficiency syndrome. In: Journal of Hepatology. 1986 ; Vol. 2, No. 3. pp. 475-484.
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