The sorbitol shunt in the retina and the optic nerve of mice with inherited and STZ-induced diabetes

P. Naeser, S. E. Brolin, P. O. Berggren

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Micromethods designed for studying the sorbitol shunt permitted studies of the retina and the optic nerve from mice. A significant accumulation of sorbitol was found in the retina of 5-months-old obese-hyper-glycaemic and severely STZ diabetic mice. The latter mice also showed increased sorbitol concentrations in the optic nerve. The activities of aldose reductase were about 3 times higher in the optic nerve than in the retina. Our findings show that not only the retina but also the optic nerve accumulates sorbitol. It is suggested that this hypothetically may lead to degeneration of the optic nerve in severe diabetes as in peripheral nerves.

Original languageEnglish
Pages (from-to)693-698
Number of pages6
JournalActa Ophthalmologica
Volume65
Issue number6
StatePublished - Dec 1 1987
Externally publishedYes

Fingerprint

Sorbitol
Optic Nerve
Retina
Aldehyde Reductase
Peripheral Nerves

ASJC Scopus subject areas

  • Ophthalmology

Cite this

The sorbitol shunt in the retina and the optic nerve of mice with inherited and STZ-induced diabetes. / Naeser, P.; Brolin, S. E.; Berggren, P. O.

In: Acta Ophthalmologica, Vol. 65, No. 6, 01.12.1987, p. 693-698.

Research output: Contribution to journalArticle

Naeser, P. ; Brolin, S. E. ; Berggren, P. O. / The sorbitol shunt in the retina and the optic nerve of mice with inherited and STZ-induced diabetes. In: Acta Ophthalmologica. 1987 ; Vol. 65, No. 6. pp. 693-698.
@article{1c332f9b8a324a00b9afffe2a257fa0e,
title = "The sorbitol shunt in the retina and the optic nerve of mice with inherited and STZ-induced diabetes",
abstract = "Micromethods designed for studying the sorbitol shunt permitted studies of the retina and the optic nerve from mice. A significant accumulation of sorbitol was found in the retina of 5-months-old obese-hyper-glycaemic and severely STZ diabetic mice. The latter mice also showed increased sorbitol concentrations in the optic nerve. The activities of aldose reductase were about 3 times higher in the optic nerve than in the retina. Our findings show that not only the retina but also the optic nerve accumulates sorbitol. It is suggested that this hypothetically may lead to degeneration of the optic nerve in severe diabetes as in peripheral nerves.",
author = "P. Naeser and Brolin, {S. E.} and Berggren, {P. O.}",
year = "1987",
month = "12",
day = "1",
language = "English",
volume = "65",
pages = "693--698",
journal = "Acta Ophthalmologica",
issn = "1755-375X",
publisher = "Copenhagen Scriptor",
number = "6",

}

TY - JOUR

T1 - The sorbitol shunt in the retina and the optic nerve of mice with inherited and STZ-induced diabetes

AU - Naeser, P.

AU - Brolin, S. E.

AU - Berggren, P. O.

PY - 1987/12/1

Y1 - 1987/12/1

N2 - Micromethods designed for studying the sorbitol shunt permitted studies of the retina and the optic nerve from mice. A significant accumulation of sorbitol was found in the retina of 5-months-old obese-hyper-glycaemic and severely STZ diabetic mice. The latter mice also showed increased sorbitol concentrations in the optic nerve. The activities of aldose reductase were about 3 times higher in the optic nerve than in the retina. Our findings show that not only the retina but also the optic nerve accumulates sorbitol. It is suggested that this hypothetically may lead to degeneration of the optic nerve in severe diabetes as in peripheral nerves.

AB - Micromethods designed for studying the sorbitol shunt permitted studies of the retina and the optic nerve from mice. A significant accumulation of sorbitol was found in the retina of 5-months-old obese-hyper-glycaemic and severely STZ diabetic mice. The latter mice also showed increased sorbitol concentrations in the optic nerve. The activities of aldose reductase were about 3 times higher in the optic nerve than in the retina. Our findings show that not only the retina but also the optic nerve accumulates sorbitol. It is suggested that this hypothetically may lead to degeneration of the optic nerve in severe diabetes as in peripheral nerves.

UR - http://www.scopus.com/inward/record.url?scp=0023573016&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023573016&partnerID=8YFLogxK

M3 - Article

C2 - 3434235

AN - SCOPUS:0023573016

VL - 65

SP - 693

EP - 698

JO - Acta Ophthalmologica

JF - Acta Ophthalmologica

SN - 1755-375X

IS - 6

ER -