The Slavic NBN Founder Mutation: A Role for Reproductive Fitness?

Eva Seemanova, Raymonda Varon, Jan Vejvalka, Petr Jarolim, Pavel Seeman, Krystyna H. Chrzanowska, Martin Digweed, Igor Resnick, Ivo Kremensky, Kathrin Saar, Katrin Hoffmann, Véronique Dutrannoy, Mohsen Karbasiyan, Mehdi Ghani, Ivo Barić, Mustafa Tekin, Peter Kovacs, Michael Krawczak, André Reis, Karl SperlingMichael Nothnagel

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The vast majority of patients with Nijmegen Breakage Syndrome (NBS) are of Slavic origin and carry a deleterious deletion (c.657del5; rs587776650) in the NBN gene on chromosome 8q21. This mutation is essentially confined to Slavic populations and may thus be considered a Slavic founder mutation. Notably, not a single parenthood of a homozygous c.657del5 carrier has been reported to date, while heterozygous carriers do reproduce but have an increased cancer risk. These observations seem to conflict with the considerable carrier frequency of c.657del5 of 0.5% to 1% as observed in different Slavic populations because deleterious mutations would be eliminated quite rapidly by purifying selection. Therefore, we propose that heterozygous c.657del5 carriers have increased reproductive success, i.e., that the mutation confers heterozygote advantage. In fact, in our cohort study of the reproductive history of 24 NBS pedigrees from the Czech Republic, we observed that female carriers gave birth to more children on average than female non-carriers, while no such reproductive differences were observed for males. We also estimate that c.657del5 likely occurred less than 300 generations ago, thus supporting the view that the original mutation predated the historic split and subsequent spread of the 'Slavic people'. We surmise that the higher fertility of female c.657del5 carriers reflects a lower miscarriage rate in these women, thereby reflecting the role of the NBN gene product, nibrin, in the repair of DNA double strand breaks and their processing in immune gene rearrangements, telomere maintenance, and meiotic recombination, akin to the previously described role of the DNA repair genes BRCA1 and BRCA2.

Original languageEnglish (US)
Article numbere0167984
JournalPLoS One
Volume11
Issue number12
DOIs
StatePublished - Dec 1 2016
Externally publishedYes

Fingerprint

Genetic Fitness
Genes
mutation
Mutation
Nijmegen Breakage Syndrome
DNA repair
Repair
genes
BRCA2 Gene
DNA
BRCA1 Gene
parenting
Chromosomes
Reproductive History
abortion (animals)
female fertility
Double-Stranded DNA Breaks
Gene Rearrangement
Czech Republic
telomeres

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Seemanova, E., Varon, R., Vejvalka, J., Jarolim, P., Seeman, P., Chrzanowska, K. H., ... Nothnagel, M. (2016). The Slavic NBN Founder Mutation: A Role for Reproductive Fitness? PLoS One, 11(12), [e0167984]. https://doi.org/10.1371/journal.pone.0167984

The Slavic NBN Founder Mutation : A Role for Reproductive Fitness? / Seemanova, Eva; Varon, Raymonda; Vejvalka, Jan; Jarolim, Petr; Seeman, Pavel; Chrzanowska, Krystyna H.; Digweed, Martin; Resnick, Igor; Kremensky, Ivo; Saar, Kathrin; Hoffmann, Katrin; Dutrannoy, Véronique; Karbasiyan, Mohsen; Ghani, Mehdi; Barić, Ivo; Tekin, Mustafa; Kovacs, Peter; Krawczak, Michael; Reis, André; Sperling, Karl; Nothnagel, Michael.

In: PLoS One, Vol. 11, No. 12, e0167984, 01.12.2016.

Research output: Contribution to journalArticle

Seemanova, E, Varon, R, Vejvalka, J, Jarolim, P, Seeman, P, Chrzanowska, KH, Digweed, M, Resnick, I, Kremensky, I, Saar, K, Hoffmann, K, Dutrannoy, V, Karbasiyan, M, Ghani, M, Barić, I, Tekin, M, Kovacs, P, Krawczak, M, Reis, A, Sperling, K & Nothnagel, M 2016, 'The Slavic NBN Founder Mutation: A Role for Reproductive Fitness?', PLoS One, vol. 11, no. 12, e0167984. https://doi.org/10.1371/journal.pone.0167984
Seemanova E, Varon R, Vejvalka J, Jarolim P, Seeman P, Chrzanowska KH et al. The Slavic NBN Founder Mutation: A Role for Reproductive Fitness? PLoS One. 2016 Dec 1;11(12). e0167984. https://doi.org/10.1371/journal.pone.0167984
Seemanova, Eva ; Varon, Raymonda ; Vejvalka, Jan ; Jarolim, Petr ; Seeman, Pavel ; Chrzanowska, Krystyna H. ; Digweed, Martin ; Resnick, Igor ; Kremensky, Ivo ; Saar, Kathrin ; Hoffmann, Katrin ; Dutrannoy, Véronique ; Karbasiyan, Mohsen ; Ghani, Mehdi ; Barić, Ivo ; Tekin, Mustafa ; Kovacs, Peter ; Krawczak, Michael ; Reis, André ; Sperling, Karl ; Nothnagel, Michael. / The Slavic NBN Founder Mutation : A Role for Reproductive Fitness?. In: PLoS One. 2016 ; Vol. 11, No. 12.
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