Objective: A single nucleotide polymorphism (SNP) T1128C, which causes an amino acid change from leucine(7) to proline(7) in the signal peptide of neuropeptide Y (NPY), has been found to be associated with multiple clinical parameters or disease. However, this SNP was not identified in the Japanese population. We asked if this is also true in the Korean population. Methods: Genotyping was conducted by pyrosequencing, a newly developed real-time high-throughput SNP scoring technique. Results: All 242 Korean subjects showed T1128/T1128 genotype. Conclusions: The T1128C SNP does not appear to exist in this Korean population.
- Neuropeptide Y
- Single nucleotide polymorphism
ASJC Scopus subject areas
- Pharmacology (medical)
- Pharmacology, Toxicology and Pharmaceutics(all)