The significance of family history status in relation to neuropsychological test performance and cerebral glucose metabolism studied with positron emission tomography in older alcoholic patients

Kenneth M. Adams, Sid Gilman, Douglas E Johnson-Greene, Robert A. Koeppe, Larry Junck, Karen J. Kluin, Susan Martorello, Michael J. Johnson, Mary Heumann, Elizabeth Hill

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Patients with severe chronic alcoholism have decreased rates of glucose metabolism in the medial frontal lobe and correlated abnormalities of neuropsychological functioning. The potential influence of family history of alcoholism has not been examined in these patients. In a retrospective study, we used neuropsychological tests and neuroimaging employing [18F]flourodeoxyglucose with positron emission tomography to study 48 older subjects who had histories of severe, chronic alcohol dependence. These patients ware divided into two groups: 27 with a first-degree relative with chronic alcoholism and 21 patients without first-degree relative with chronic alcoholism. No differences were found between groups on either neuropsychological or neuroimaging tests. These results suggest that a family history of alcoholism does not moderate the damaging effects of severe chronic alcoholism on the functioning of the medial frontal lobe.

Original languageEnglish
Pages (from-to)105-110
Number of pages6
JournalAlcoholism: Clinical and Experimental Research
Volume22
Issue number1
StatePublished - Feb 1 1998
Externally publishedYes

Fingerprint

Neuroimaging
Positron emission tomography
Neuropsychological Tests
Alcoholics
Metabolism
Positron-Emission Tomography
Alcoholism
Glucose
Alcohols
Frontal Lobe
Retrospective Studies

Keywords

  • Alcoholism
  • Family history
  • Neuroimaging
  • Neuropsychological tests
  • Positron emission tomography

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Toxicology

Cite this

The significance of family history status in relation to neuropsychological test performance and cerebral glucose metabolism studied with positron emission tomography in older alcoholic patients. / Adams, Kenneth M.; Gilman, Sid; Johnson-Greene, Douglas E; Koeppe, Robert A.; Junck, Larry; Kluin, Karen J.; Martorello, Susan; Johnson, Michael J.; Heumann, Mary; Hill, Elizabeth.

In: Alcoholism: Clinical and Experimental Research, Vol. 22, No. 1, 01.02.1998, p. 105-110.

Research output: Contribution to journalArticle

Adams, Kenneth M. ; Gilman, Sid ; Johnson-Greene, Douglas E ; Koeppe, Robert A. ; Junck, Larry ; Kluin, Karen J. ; Martorello, Susan ; Johnson, Michael J. ; Heumann, Mary ; Hill, Elizabeth. / The significance of family history status in relation to neuropsychological test performance and cerebral glucose metabolism studied with positron emission tomography in older alcoholic patients. In: Alcoholism: Clinical and Experimental Research. 1998 ; Vol. 22, No. 1. pp. 105-110.
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