The significance of family history status in relation to neuropsychological test performance and cerebral glucose metabolism studied with positron emission tomography in older alcoholic patients

Kenneth M. Adams, Sid Gilman, Doug Johnson-Greene, Robert A. Koeppe, Larry Junck, Karen J. Kluin, Susan Martorello, Michael J. Johnson, Mary Heumann, Elizabeth Hill

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Patients with severe chronic alcoholism have decreased rates of glucose metabolism in the medial frontal lobe and correlated abnormalities of neuropsychological functioning. The potential influence of family history of alcoholism has not been examined in these patients. In a retrospective study, we used neuropsychological tests and neuroimaging employing [18F]flourodeoxyglucose with positron emission tomography to study 48 older subjects who had histories of severe, chronic alcohol dependence. These patients ware divided into two groups: 27 with a first-degree relative with chronic alcoholism and 21 patients without first-degree relative with chronic alcoholism. No differences were found between groups on either neuropsychological or neuroimaging tests. These results suggest that a family history of alcoholism does not moderate the damaging effects of severe chronic alcoholism on the functioning of the medial frontal lobe.

Original languageEnglish (US)
Pages (from-to)105-110
Number of pages6
JournalAlcoholism: Clinical and Experimental Research
Volume22
Issue number1
DOIs
StatePublished - Feb 1998

Keywords

  • Alcoholism
  • Family history
  • Neuroimaging
  • Neuropsychological tests
  • Positron emission tomography

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Toxicology

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