Abstract
Patients with severe chronic alcoholism have decreased rates of glucose metabolism in the medial frontal lobe and correlated abnormalities of neuropsychological functioning. The potential influence of family history of alcoholism has not been examined in these patients. In a retrospective study, we used neuropsychological tests and neuroimaging employing [18F]flourodeoxyglucose with positron emission tomography to study 48 older subjects who had histories of severe, chronic alcohol dependence. These patients ware divided into two groups: 27 with a first-degree relative with chronic alcoholism and 21 patients without first-degree relative with chronic alcoholism. No differences were found between groups on either neuropsychological or neuroimaging tests. These results suggest that a family history of alcoholism does not moderate the damaging effects of severe chronic alcoholism on the functioning of the medial frontal lobe.
| Original language | English |
|---|---|
| Pages (from-to) | 105-110 |
| Number of pages | 6 |
| Journal | Alcoholism: Clinical and Experimental Research |
| Volume | 22 |
| Issue number | 1 |
| State | Published - Feb 1 1998 |
| Externally published | Yes |
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Keywords
- Alcoholism
- Family history
- Neuroimaging
- Neuropsychological tests
- Positron emission tomography
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Toxicology
Cite this
The significance of family history status in relation to neuropsychological test performance and cerebral glucose metabolism studied with positron emission tomography in older alcoholic patients. / Adams, Kenneth M.; Gilman, Sid; Johnson-Greene, Douglas E; Koeppe, Robert A.; Junck, Larry; Kluin, Karen J.; Martorello, Susan; Johnson, Michael J.; Heumann, Mary; Hill, Elizabeth.
In: Alcoholism: Clinical and Experimental Research, Vol. 22, No. 1, 01.02.1998, p. 105-110.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The significance of family history status in relation to neuropsychological test performance and cerebral glucose metabolism studied with positron emission tomography in older alcoholic patients
AU - Adams, Kenneth M.
AU - Gilman, Sid
AU - Johnson-Greene, Douglas E
AU - Koeppe, Robert A.
AU - Junck, Larry
AU - Kluin, Karen J.
AU - Martorello, Susan
AU - Johnson, Michael J.
AU - Heumann, Mary
AU - Hill, Elizabeth
PY - 1998/2/1
Y1 - 1998/2/1
N2 - Patients with severe chronic alcoholism have decreased rates of glucose metabolism in the medial frontal lobe and correlated abnormalities of neuropsychological functioning. The potential influence of family history of alcoholism has not been examined in these patients. In a retrospective study, we used neuropsychological tests and neuroimaging employing [18F]flourodeoxyglucose with positron emission tomography to study 48 older subjects who had histories of severe, chronic alcohol dependence. These patients ware divided into two groups: 27 with a first-degree relative with chronic alcoholism and 21 patients without first-degree relative with chronic alcoholism. No differences were found between groups on either neuropsychological or neuroimaging tests. These results suggest that a family history of alcoholism does not moderate the damaging effects of severe chronic alcoholism on the functioning of the medial frontal lobe.
AB - Patients with severe chronic alcoholism have decreased rates of glucose metabolism in the medial frontal lobe and correlated abnormalities of neuropsychological functioning. The potential influence of family history of alcoholism has not been examined in these patients. In a retrospective study, we used neuropsychological tests and neuroimaging employing [18F]flourodeoxyglucose with positron emission tomography to study 48 older subjects who had histories of severe, chronic alcohol dependence. These patients ware divided into two groups: 27 with a first-degree relative with chronic alcoholism and 21 patients without first-degree relative with chronic alcoholism. No differences were found between groups on either neuropsychological or neuroimaging tests. These results suggest that a family history of alcoholism does not moderate the damaging effects of severe chronic alcoholism on the functioning of the medial frontal lobe.
KW - Alcoholism
KW - Family history
KW - Neuroimaging
KW - Neuropsychological tests
KW - Positron emission tomography
UR - http://www.scopus.com/inward/record.url?scp=0031934640&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031934640&partnerID=8YFLogxK
M3 - Article
VL - 22
SP - 105
EP - 110
JO - Alcoholism: Clinical and Experimental Research
JF - Alcoholism: Clinical and Experimental Research
SN - 0145-6008
IS - 1
ER -