The scale-invariance of spatial patterning in a developing system

Balakrishna L. Lokeshwar, Vidyanand Nanjundiah

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Regulating systems, that is, those which exhibit scale-invariant patterns in the adult, are supposed, to do so on account of interactions between cells during development. The nature of these interactions has to be such that the system of positional information ("map") in the embryo also regulates. To our knowledge, this supposition regarding a regulating map has not been subjected to a direct test in any embryonic system. Here we do so by means of a simple and novel criterion and use it to examine tip regeneration in the mulicellular stage (slug) of Dictyostelium discoideum. When anterior, tip-containing fragments of slugs are amputated, a new tip spontaneously regenerates at the cut surface of the (remaining) posterior fragment. The time needed for regeneration to occur depends on the relative size of the amputated fragment but is independent of the total size of the slug. We conclude from this finding that there is at least one system underlying positional information in the slug which regulates.

Original languageEnglish
Pages (from-to)361-364
Number of pages4
JournalWilhelm Roux's Archives of Developmental Biology
Volume190
Issue number6
DOIs
StatePublished - Nov 1 1981
Externally publishedYes

Fingerprint

Gastropoda
slugs
slug
Regeneration
regeneration
Dictyostelium discoideum
Dictyostelium
Information Systems
Cell Communication
embryo
embryo (animal)
Embryonic Structures
testing
cells

Keywords

  • Dictyostelium
  • Positional Information
  • Regeneration
  • Regulation

ASJC Scopus subject areas

  • Developmental Biology

Cite this

The scale-invariance of spatial patterning in a developing system. / Lokeshwar, Balakrishna L.; Nanjundiah, Vidyanand.

In: Wilhelm Roux's Archives of Developmental Biology, Vol. 190, No. 6, 01.11.1981, p. 361-364.

Research output: Contribution to journalArticle

Lokeshwar, Balakrishna L. ; Nanjundiah, Vidyanand. / The scale-invariance of spatial patterning in a developing system. In: Wilhelm Roux's Archives of Developmental Biology. 1981 ; Vol. 190, No. 6. pp. 361-364.
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