The safety and efficacy of naftifine cream 1% in the treatment of tinea pedis

L. A. Schachner, F. K. Bagatell, C. V. Whittington, I. Willis, J. Sefton, R. E. DeGryse

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Naftifine cream 1% was compared with its vehicle during a 6-week, double-blind, randomized, parallel-group study of 91 subjects with tinea pedis. After 4 weeks of twice-daily treatment, 57% of the subjects treated with naftifine and 38% of those treated with its vehicle had negative microscopic findings and negative fungal cultures (p=0.038). Two weeks after the conclusion of treatment (week 6), 62% of the naftifine group and 29% of the vehicle group had negative mycological findings (p=0.002). Naftfine was significantly more effective than its vehicle in reducing fungal scaling and fissuring (p<0.04). It was concluded that naftifine cream 1% is safe and significantly more effective than its vehicle in treating tinea pedis.

Original languageEnglish (US)
Pages (from-to)148-152
Number of pages5
JournalAdvances in Therapy
Volume7
Issue number3
StatePublished - Jan 1 1990
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology (medical)

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    Schachner, L. A., Bagatell, F. K., Whittington, C. V., Willis, I., Sefton, J., & DeGryse, R. E. (1990). The safety and efficacy of naftifine cream 1% in the treatment of tinea pedis. Advances in Therapy, 7(3), 148-152.