The S cell

An interneuron essential for sensitization and full dishabituation of leech shortening

Christie L. Sahley, Barbara K. Modney, Nicholas M. Boulis, Kenneth J Muller

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

Sensory neurons in the leech excite the S interneuron, which in turn excites motoneurons that shorten the leech, although activity in the S cell reportedly cannot by itself shorten the animal. Experiments were performed in semi-intact leeches using established dishabituation and sensitization protocols. S-cell activity increased during reflexive shortening once the animal was sensitized or dishabituated with a strong shock. S-cell activity otherwise was not associated with shortening. To test the role of the S-cell in dishabituation and sensitization of the shortening reflex, single S cells were ablated in vivo by intracellular injections of pronase. S-cell lesions reduced but did not eliminate dishabituation; however, sensitization was completely disrupted. This was consistent with recent evidence that separate processes contribute to dishabituation and sensitization. Since the S cell in each ganglion is a link in a rapidly conducting chain along the length of the animal, it may be sufficient to break the chain at a single point to eliminate sensitization.

Original languageEnglish
Pages (from-to)6715-6721
Number of pages7
JournalJournal of Neuroscience
Volume14
Issue number11 I
StatePublished - Nov 15 1994

Fingerprint

Leeches
Interneurons
Pronase
Motor Neurons
Sensory Receptor Cells
Ganglia
Reflex
Shock
Injections

Keywords

  • dishabituation
  • learning
  • leech
  • S-cell
  • S-cell ablation
  • sensitization

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

The S cell : An interneuron essential for sensitization and full dishabituation of leech shortening. / Sahley, Christie L.; Modney, Barbara K.; Boulis, Nicholas M.; Muller, Kenneth J.

In: Journal of Neuroscience, Vol. 14, No. 11 I, 15.11.1994, p. 6715-6721.

Research output: Contribution to journalArticle

Sahley, Christie L. ; Modney, Barbara K. ; Boulis, Nicholas M. ; Muller, Kenneth J. / The S cell : An interneuron essential for sensitization and full dishabituation of leech shortening. In: Journal of Neuroscience. 1994 ; Vol. 14, No. 11 I. pp. 6715-6721.
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