The Role of Vascular Endothelial Growth Factor in Wound Healing

Philip Bao, Arber Kodra, Marjana Tomic-Canic, Michael S. Golinko, H. Paul Ehrlich, Harold Brem

Research output: Contribution to journalArticle

450 Citations (Scopus)

Abstract

Background: A chronic wound is tissue with an impaired ability to heal. This is often a consequence of one of the following etiologies: diabetes, venous reflux, arterial insufficiency sickle cell disease, steroids, and/or pressure. Healing requires granulation tissue depending on epithelialization and angiogenesis. Currently no growth factor is available to treat patients with impaired healing that stimulates both epithelialization and angiogenesis. The objective is to review is the multiple mechanisms of vascular endothelial growth factor (VEGF) in wound healing. Materials and Methods: The authors reviewed the literature on the structure and function of VEGF, including its use for therapeutic angiogenesis. Particular attention is given to the specific role of VEGF in the angiogenesis cascade, its relationship to other growth factors and cells in a healing wound. Results: VEGF is released by a variety of cells and stimulates multiple components of the angiogenic cascade. It is up-regulated during the early days of healing, when capillary growth is maximal. Studies have shown the efficacy of VEGF in peripheral and cardiac ischemic vascular disease with minimal adverse effects. Experimental data supports the hypothesis that VEGF stimulates epithelialization and collagen deposition in a wound. Conclusion: VEGF stimulates wound healing through angiogenesis, but likely promotes collagen deposition and epithelialization as well. Further study of the molecule by utilizing the protein itself, or novel forms of delivery such as gene therapy, will increase its therapeutic possibilities to accelerate closure of a chronic wound.

Original languageEnglish
Pages (from-to)347-358
Number of pages12
JournalJournal of Surgical Research
Volume153
Issue number2
DOIs
StatePublished - May 15 2009
Externally publishedYes

Fingerprint

Wound Healing
Vascular Endothelial Growth Factor A
Intercellular Signaling Peptides and Proteins
Wounds and Injuries
Collagen
Granulation Tissue
Sickle Cell Anemia
Therapeutic Uses
Vascular Diseases
Genetic Therapy
Steroids
Pressure
Growth
Proteins

Keywords

  • angiogenesis
  • epithelialization
  • fibroblast
  • keratinocyte
  • VEGF
  • wound healing

ASJC Scopus subject areas

  • Surgery

Cite this

The Role of Vascular Endothelial Growth Factor in Wound Healing. / Bao, Philip; Kodra, Arber; Tomic-Canic, Marjana; Golinko, Michael S.; Ehrlich, H. Paul; Brem, Harold.

In: Journal of Surgical Research, Vol. 153, No. 2, 15.05.2009, p. 347-358.

Research output: Contribution to journalArticle

Bao, Philip ; Kodra, Arber ; Tomic-Canic, Marjana ; Golinko, Michael S. ; Ehrlich, H. Paul ; Brem, Harold. / The Role of Vascular Endothelial Growth Factor in Wound Healing. In: Journal of Surgical Research. 2009 ; Vol. 153, No. 2. pp. 347-358.
@article{970e8c0527054427902228326b014c5e,
title = "The Role of Vascular Endothelial Growth Factor in Wound Healing",
abstract = "Background: A chronic wound is tissue with an impaired ability to heal. This is often a consequence of one of the following etiologies: diabetes, venous reflux, arterial insufficiency sickle cell disease, steroids, and/or pressure. Healing requires granulation tissue depending on epithelialization and angiogenesis. Currently no growth factor is available to treat patients with impaired healing that stimulates both epithelialization and angiogenesis. The objective is to review is the multiple mechanisms of vascular endothelial growth factor (VEGF) in wound healing. Materials and Methods: The authors reviewed the literature on the structure and function of VEGF, including its use for therapeutic angiogenesis. Particular attention is given to the specific role of VEGF in the angiogenesis cascade, its relationship to other growth factors and cells in a healing wound. Results: VEGF is released by a variety of cells and stimulates multiple components of the angiogenic cascade. It is up-regulated during the early days of healing, when capillary growth is maximal. Studies have shown the efficacy of VEGF in peripheral and cardiac ischemic vascular disease with minimal adverse effects. Experimental data supports the hypothesis that VEGF stimulates epithelialization and collagen deposition in a wound. Conclusion: VEGF stimulates wound healing through angiogenesis, but likely promotes collagen deposition and epithelialization as well. Further study of the molecule by utilizing the protein itself, or novel forms of delivery such as gene therapy, will increase its therapeutic possibilities to accelerate closure of a chronic wound.",
keywords = "angiogenesis, epithelialization, fibroblast, keratinocyte, VEGF, wound healing",
author = "Philip Bao and Arber Kodra and Marjana Tomic-Canic and Golinko, {Michael S.} and Ehrlich, {H. Paul} and Harold Brem",
year = "2009",
month = "5",
day = "15",
doi = "10.1016/j.jss.2008.04.023",
language = "English",
volume = "153",
pages = "347--358",
journal = "Journal of Surgical Research",
issn = "0022-4804",
publisher = "Academic Press Inc.",
number = "2",

}

TY - JOUR

T1 - The Role of Vascular Endothelial Growth Factor in Wound Healing

AU - Bao, Philip

AU - Kodra, Arber

AU - Tomic-Canic, Marjana

AU - Golinko, Michael S.

AU - Ehrlich, H. Paul

AU - Brem, Harold

PY - 2009/5/15

Y1 - 2009/5/15

N2 - Background: A chronic wound is tissue with an impaired ability to heal. This is often a consequence of one of the following etiologies: diabetes, venous reflux, arterial insufficiency sickle cell disease, steroids, and/or pressure. Healing requires granulation tissue depending on epithelialization and angiogenesis. Currently no growth factor is available to treat patients with impaired healing that stimulates both epithelialization and angiogenesis. The objective is to review is the multiple mechanisms of vascular endothelial growth factor (VEGF) in wound healing. Materials and Methods: The authors reviewed the literature on the structure and function of VEGF, including its use for therapeutic angiogenesis. Particular attention is given to the specific role of VEGF in the angiogenesis cascade, its relationship to other growth factors and cells in a healing wound. Results: VEGF is released by a variety of cells and stimulates multiple components of the angiogenic cascade. It is up-regulated during the early days of healing, when capillary growth is maximal. Studies have shown the efficacy of VEGF in peripheral and cardiac ischemic vascular disease with minimal adverse effects. Experimental data supports the hypothesis that VEGF stimulates epithelialization and collagen deposition in a wound. Conclusion: VEGF stimulates wound healing through angiogenesis, but likely promotes collagen deposition and epithelialization as well. Further study of the molecule by utilizing the protein itself, or novel forms of delivery such as gene therapy, will increase its therapeutic possibilities to accelerate closure of a chronic wound.

AB - Background: A chronic wound is tissue with an impaired ability to heal. This is often a consequence of one of the following etiologies: diabetes, venous reflux, arterial insufficiency sickle cell disease, steroids, and/or pressure. Healing requires granulation tissue depending on epithelialization and angiogenesis. Currently no growth factor is available to treat patients with impaired healing that stimulates both epithelialization and angiogenesis. The objective is to review is the multiple mechanisms of vascular endothelial growth factor (VEGF) in wound healing. Materials and Methods: The authors reviewed the literature on the structure and function of VEGF, including its use for therapeutic angiogenesis. Particular attention is given to the specific role of VEGF in the angiogenesis cascade, its relationship to other growth factors and cells in a healing wound. Results: VEGF is released by a variety of cells and stimulates multiple components of the angiogenic cascade. It is up-regulated during the early days of healing, when capillary growth is maximal. Studies have shown the efficacy of VEGF in peripheral and cardiac ischemic vascular disease with minimal adverse effects. Experimental data supports the hypothesis that VEGF stimulates epithelialization and collagen deposition in a wound. Conclusion: VEGF stimulates wound healing through angiogenesis, but likely promotes collagen deposition and epithelialization as well. Further study of the molecule by utilizing the protein itself, or novel forms of delivery such as gene therapy, will increase its therapeutic possibilities to accelerate closure of a chronic wound.

KW - angiogenesis

KW - epithelialization

KW - fibroblast

KW - keratinocyte

KW - VEGF

KW - wound healing

UR - http://www.scopus.com/inward/record.url?scp=64849116779&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=64849116779&partnerID=8YFLogxK

U2 - 10.1016/j.jss.2008.04.023

DO - 10.1016/j.jss.2008.04.023

M3 - Article

VL - 153

SP - 347

EP - 358

JO - Journal of Surgical Research

JF - Journal of Surgical Research

SN - 0022-4804

IS - 2

ER -