The role of troponins in muscle contraction

Aldrin V. Gomes; James D. Potter; Danuta Szczesna-Cordary

doi:10.1080/15216540216037

The role of troponins in muscle contraction

Aldrin V. Gomes, James D. Potter, Danuta Szczesna-Cordary

Molecular and Cellular Pharmacology

Research output: Contribution to journal › Review article › peer-review

100 Scopus citations

Abstract

Troponin (Tn) is the sarcomeric Ca²⁺ regulator for striated (skeletal and cardiac) muscle contraction. On binding Ca²⁺ Tn transmits information via structural changes throughout the actintropomyosin filaments, activating myosin ATPase activity and muscle contraction. Although the Tn-mediated regulation of striated muscle contraction is now well understood, the role of different Tn isoforms in these processes is the subject of intensive investigations. This review addresses the physiological significance of the multiple Tn isoforms in skeletal and cardiac muscles as well as their role in the regulation of contraction.

Original language	English (US)
Pages (from-to)	323-333
Number of pages	11
Journal	IUBMB life
Volume	54
Issue number	6
DOIs	https://doi.org/10.1080/15216540216037
State	Published - Dec 1 2002

Keywords

Myopathies
Striated muscle regulation
Troponin isoforms

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Genetics
Cell Biology

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AU - Potter, James D.

AU - Szczesna-Cordary, Danuta

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N2 - Troponin (Tn) is the sarcomeric Ca2+ regulator for striated (skeletal and cardiac) muscle contraction. On binding Ca2+ Tn transmits information via structural changes throughout the actintropomyosin filaments, activating myosin ATPase activity and muscle contraction. Although the Tn-mediated regulation of striated muscle contraction is now well understood, the role of different Tn isoforms in these processes is the subject of intensive investigations. This review addresses the physiological significance of the multiple Tn isoforms in skeletal and cardiac muscles as well as their role in the regulation of contraction.

AB - Troponin (Tn) is the sarcomeric Ca2+ regulator for striated (skeletal and cardiac) muscle contraction. On binding Ca2+ Tn transmits information via structural changes throughout the actintropomyosin filaments, activating myosin ATPase activity and muscle contraction. Although the Tn-mediated regulation of striated muscle contraction is now well understood, the role of different Tn isoforms in these processes is the subject of intensive investigations. This review addresses the physiological significance of the multiple Tn isoforms in skeletal and cardiac muscles as well as their role in the regulation of contraction.

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KW - Striated muscle regulation

KW - Troponin isoforms

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The role of troponins in muscle contraction

Abstract

Keywords

ASJC Scopus subject areas

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