The role of troponins in muscle contraction

Aldrin V. Gomes, James D. Potter, Danuta Szczesna-Cordary

Research output: Contribution to journalReview articlepeer-review

110 Scopus citations


Troponin (Tn) is the sarcomeric Ca2+ regulator for striated (skeletal and cardiac) muscle contraction. On binding Ca2+ Tn transmits information via structural changes throughout the actintropomyosin filaments, activating myosin ATPase activity and muscle contraction. Although the Tn-mediated regulation of striated muscle contraction is now well understood, the role of different Tn isoforms in these processes is the subject of intensive investigations. This review addresses the physiological significance of the multiple Tn isoforms in skeletal and cardiac muscles as well as their role in the regulation of contraction.

Original languageEnglish (US)
Pages (from-to)323-333
Number of pages11
JournalIUBMB life
Issue number6
StatePublished - Dec 1 2002


  • Myopathies
  • Striated muscle regulation
  • Troponin isoforms

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology


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