Abstract
Troponin (Tn) is the sarcomeric Ca2+ regulator for striated (skeletal and cardiac) muscle contraction. On binding Ca2+ Tn transmits information via structural changes throughout the actintropomyosin filaments, activating myosin ATPase activity and muscle contraction. Although the Tn-mediated regulation of striated muscle contraction is now well understood, the role of different Tn isoforms in these processes is the subject of intensive investigations. This review addresses the physiological significance of the multiple Tn isoforms in skeletal and cardiac muscles as well as their role in the regulation of contraction.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 323-333 |
| Number of pages | 11 |
| Journal | IUBMB life |
| Volume | 54 |
| Issue number | 6 |
| DOIs | |
| State | Published - Dec 1 2002 |
Keywords
- Myopathies
- Striated muscle regulation
- Troponin isoforms
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Genetics
- Cell Biology
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Cite this
Gomes, A. V., Potter, J. D., & Szczesna-Cordary, D. (2002). The role of troponins in muscle contraction. IUBMB life, 54(6), 323-333. https://doi.org/10.1080/15216540216037