The role of troponins in muscle contraction

Aldrin V. Gomes; James D. Potter; Danuta Szczesna-Cordary

doi:10.1080/15216540216037

The role of troponins in muscle contraction

Aldrin V. Gomes, James D. Potter, Danuta Szczesna-Cordary

Molecular and Cellular Pharmacology

Research output: Contribution to journal › Review article › peer-review

101 Scopus citations

Abstract

Troponin (Tn) is the sarcomeric Ca²⁺ regulator for striated (skeletal and cardiac) muscle contraction. On binding Ca²⁺ Tn transmits information via structural changes throughout the actintropomyosin filaments, activating myosin ATPase activity and muscle contraction. Although the Tn-mediated regulation of striated muscle contraction is now well understood, the role of different Tn isoforms in these processes is the subject of intensive investigations. This review addresses the physiological significance of the multiple Tn isoforms in skeletal and cardiac muscles as well as their role in the regulation of contraction.

Original language	English (US)
Pages (from-to)	323-333
Number of pages	11
Journal	IUBMB life
Volume	54
Issue number	6
DOIs	https://doi.org/10.1080/15216540216037
State	Published - Dec 1 2002

Keywords

Myopathies
Striated muscle regulation
Troponin isoforms

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Genetics
Cell Biology

Access to Document

10.1080/15216540216037

Cite this

@article{3026b68420194aa3a46be7d9bca1b324,

title = "The role of troponins in muscle contraction",

abstract = "Troponin (Tn) is the sarcomeric Ca2+ regulator for striated (skeletal and cardiac) muscle contraction. On binding Ca2+ Tn transmits information via structural changes throughout the actintropomyosin filaments, activating myosin ATPase activity and muscle contraction. Although the Tn-mediated regulation of striated muscle contraction is now well understood, the role of different Tn isoforms in these processes is the subject of intensive investigations. This review addresses the physiological significance of the multiple Tn isoforms in skeletal and cardiac muscles as well as their role in the regulation of contraction.",

keywords = "Myopathies, Striated muscle regulation, Troponin isoforms",

author = "Gomes, {Aldrin V.} and Potter, {James D.} and Danuta Szczesna-Cordary",

year = "2002",

month = dec,

day = "1",

doi = "10.1080/15216540216037",

language = "English (US)",

volume = "54",

pages = "323--333",

journal = "Biochemistry and Molecular Biology International",

issn = "1521-6543",

publisher = "Wiley-Blackwell",

number = "6",

}

TY - JOUR

T1 - The role of troponins in muscle contraction

AU - Gomes, Aldrin V.

AU - Potter, James D.

AU - Szczesna-Cordary, Danuta

PY - 2002/12/1

Y1 - 2002/12/1

N2 - Troponin (Tn) is the sarcomeric Ca2+ regulator for striated (skeletal and cardiac) muscle contraction. On binding Ca2+ Tn transmits information via structural changes throughout the actintropomyosin filaments, activating myosin ATPase activity and muscle contraction. Although the Tn-mediated regulation of striated muscle contraction is now well understood, the role of different Tn isoforms in these processes is the subject of intensive investigations. This review addresses the physiological significance of the multiple Tn isoforms in skeletal and cardiac muscles as well as their role in the regulation of contraction.

AB - Troponin (Tn) is the sarcomeric Ca2+ regulator for striated (skeletal and cardiac) muscle contraction. On binding Ca2+ Tn transmits information via structural changes throughout the actintropomyosin filaments, activating myosin ATPase activity and muscle contraction. Although the Tn-mediated regulation of striated muscle contraction is now well understood, the role of different Tn isoforms in these processes is the subject of intensive investigations. This review addresses the physiological significance of the multiple Tn isoforms in skeletal and cardiac muscles as well as their role in the regulation of contraction.

KW - Myopathies

KW - Striated muscle regulation

KW - Troponin isoforms

UR - http://www.scopus.com/inward/record.url?scp=0036926568&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036926568&partnerID=8YFLogxK

U2 - 10.1080/15216540216037

DO - 10.1080/15216540216037

M3 - Review article

C2 - 12665242

AN - SCOPUS:0036926568

VL - 54

SP - 323

EP - 333

JO - Biochemistry and Molecular Biology International

JF - Biochemistry and Molecular Biology International

SN - 1521-6543

IS - 6

ER -

The role of troponins in muscle contraction

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this