Abstract
Troponin (Tn) is the sarcomeric Ca2+ regulator for striated (skeletal and cardiac) muscle contraction. On binding Ca2+ Tn transmits information via structural changes throughout the actintropomyosin filaments, activating myosin ATPase activity and muscle contraction. Although the Tn-mediated regulation of striated muscle contraction is now well understood, the role of different Tn isoforms in these processes is the subject of intensive investigations. This review addresses the physiological significance of the multiple Tn isoforms in skeletal and cardiac muscles as well as their role in the regulation of contraction.
| Original language | English |
|---|---|
| Pages (from-to) | 323-333 |
| Number of pages | 11 |
| Journal | IUBMB Life |
| Volume | 54 |
| Issue number | 6 |
| DOIs | |
| State | Published - Dec 1 2002 |
Fingerprint
Keywords
- Myopathies
- Striated muscle regulation
- Troponin isoforms
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Genetics
- Cell Biology
Cite this
The role of troponins in muscle contraction. / Gomes, Aldrin V.; Potter, James D.; Szczesna-Cordary, Danuta.
In: IUBMB Life, Vol. 54, No. 6, 01.12.2002, p. 323-333.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The role of troponins in muscle contraction
AU - Gomes, Aldrin V.
AU - Potter, James D.
AU - Szczesna-Cordary, Danuta
PY - 2002/12/1
Y1 - 2002/12/1
N2 - Troponin (Tn) is the sarcomeric Ca2+ regulator for striated (skeletal and cardiac) muscle contraction. On binding Ca2+ Tn transmits information via structural changes throughout the actintropomyosin filaments, activating myosin ATPase activity and muscle contraction. Although the Tn-mediated regulation of striated muscle contraction is now well understood, the role of different Tn isoforms in these processes is the subject of intensive investigations. This review addresses the physiological significance of the multiple Tn isoforms in skeletal and cardiac muscles as well as their role in the regulation of contraction.
AB - Troponin (Tn) is the sarcomeric Ca2+ regulator for striated (skeletal and cardiac) muscle contraction. On binding Ca2+ Tn transmits information via structural changes throughout the actintropomyosin filaments, activating myosin ATPase activity and muscle contraction. Although the Tn-mediated regulation of striated muscle contraction is now well understood, the role of different Tn isoforms in these processes is the subject of intensive investigations. This review addresses the physiological significance of the multiple Tn isoforms in skeletal and cardiac muscles as well as their role in the regulation of contraction.
KW - Myopathies
KW - Striated muscle regulation
KW - Troponin isoforms
UR - http://www.scopus.com/inward/record.url?scp=0036926568&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036926568&partnerID=8YFLogxK
U2 - 10.1080/15216540216037
DO - 10.1080/15216540216037
M3 - Article
VL - 54
SP - 323
EP - 333
JO - IUBMB Life
JF - IUBMB Life
SN - 1521-6543
IS - 6
ER -