The role of thyroid hormone and brown adipose tissue in energy homoeostasis

Antonio C. Bianco, Elizabeth A. McAninch

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

The presence of brown adipose tissue (BAT) in adults has become increasingly well defined as a result of functional imaging studies of thermogenically active BAT. Findings from these studies have created a surge of scientific interest in BAT, because it represents a potential therapeutic target for obesity-a condition with profound health consequences and few successful therapies. BAT contributes to overall energy expenditure in small mammals and neonates through adaptive thermogenesis. Thyroid-hormone signalling, particularly through induction of type II deiodinase, has a central role in brown adipogenesis in vitro and BAT development in mouse embryos. Additionally, because of high intracellular expression of type II deiodinase, adult BAT has enhanced thyroid-hormone signalling with several thyroid-hormone-dependent thermogenic pathways, including expression of the genes Ppargc1a and Ucp1. BAT thermogenesis explains the essential part played by thyroid hormone in energy homoeostasis and adaptation to cold. Stimulation of BAT in adults, specifically through thyroid-hormone-mediated pathways, is a promising therapeutic target for obesity.

Original languageEnglish
Pages (from-to)250-258
Number of pages9
JournalThe Lancet Diabetes and Endocrinology
Volume1
Issue number3
DOIs
StatePublished - Nov 1 2013

Fingerprint

Brown Adipose Tissue
Thyroid Hormones
Homeostasis
Iodide Peroxidase
Thermogenesis
Obesity
Adipogenesis
Energy Metabolism
Mammals
Therapeutics
Embryonic Structures
Gene Expression
Health

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine
  • Endocrinology

Cite this

The role of thyroid hormone and brown adipose tissue in energy homoeostasis. / Bianco, Antonio C.; McAninch, Elizabeth A.

In: The Lancet Diabetes and Endocrinology, Vol. 1, No. 3, 01.11.2013, p. 250-258.

Research output: Contribution to journalArticle

Bianco, Antonio C. ; McAninch, Elizabeth A. / The role of thyroid hormone and brown adipose tissue in energy homoeostasis. In: The Lancet Diabetes and Endocrinology. 2013 ; Vol. 1, No. 3. pp. 250-258.
@article{0ee29b6affec422091d03300b37e1a88,
title = "The role of thyroid hormone and brown adipose tissue in energy homoeostasis",
abstract = "The presence of brown adipose tissue (BAT) in adults has become increasingly well defined as a result of functional imaging studies of thermogenically active BAT. Findings from these studies have created a surge of scientific interest in BAT, because it represents a potential therapeutic target for obesity-a condition with profound health consequences and few successful therapies. BAT contributes to overall energy expenditure in small mammals and neonates through adaptive thermogenesis. Thyroid-hormone signalling, particularly through induction of type II deiodinase, has a central role in brown adipogenesis in vitro and BAT development in mouse embryos. Additionally, because of high intracellular expression of type II deiodinase, adult BAT has enhanced thyroid-hormone signalling with several thyroid-hormone-dependent thermogenic pathways, including expression of the genes Ppargc1a and Ucp1. BAT thermogenesis explains the essential part played by thyroid hormone in energy homoeostasis and adaptation to cold. Stimulation of BAT in adults, specifically through thyroid-hormone-mediated pathways, is a promising therapeutic target for obesity.",
author = "Bianco, {Antonio C.} and McAninch, {Elizabeth A.}",
year = "2013",
month = "11",
day = "1",
doi = "10.1016/S2213-8587(13)70069-X",
language = "English",
volume = "1",
pages = "250--258",
journal = "The Lancet Diabetes and Endocrinology",
issn = "2213-8587",
publisher = "Elsevier BV",
number = "3",

}

TY - JOUR

T1 - The role of thyroid hormone and brown adipose tissue in energy homoeostasis

AU - Bianco, Antonio C.

AU - McAninch, Elizabeth A.

PY - 2013/11/1

Y1 - 2013/11/1

N2 - The presence of brown adipose tissue (BAT) in adults has become increasingly well defined as a result of functional imaging studies of thermogenically active BAT. Findings from these studies have created a surge of scientific interest in BAT, because it represents a potential therapeutic target for obesity-a condition with profound health consequences and few successful therapies. BAT contributes to overall energy expenditure in small mammals and neonates through adaptive thermogenesis. Thyroid-hormone signalling, particularly through induction of type II deiodinase, has a central role in brown adipogenesis in vitro and BAT development in mouse embryos. Additionally, because of high intracellular expression of type II deiodinase, adult BAT has enhanced thyroid-hormone signalling with several thyroid-hormone-dependent thermogenic pathways, including expression of the genes Ppargc1a and Ucp1. BAT thermogenesis explains the essential part played by thyroid hormone in energy homoeostasis and adaptation to cold. Stimulation of BAT in adults, specifically through thyroid-hormone-mediated pathways, is a promising therapeutic target for obesity.

AB - The presence of brown adipose tissue (BAT) in adults has become increasingly well defined as a result of functional imaging studies of thermogenically active BAT. Findings from these studies have created a surge of scientific interest in BAT, because it represents a potential therapeutic target for obesity-a condition with profound health consequences and few successful therapies. BAT contributes to overall energy expenditure in small mammals and neonates through adaptive thermogenesis. Thyroid-hormone signalling, particularly through induction of type II deiodinase, has a central role in brown adipogenesis in vitro and BAT development in mouse embryos. Additionally, because of high intracellular expression of type II deiodinase, adult BAT has enhanced thyroid-hormone signalling with several thyroid-hormone-dependent thermogenic pathways, including expression of the genes Ppargc1a and Ucp1. BAT thermogenesis explains the essential part played by thyroid hormone in energy homoeostasis and adaptation to cold. Stimulation of BAT in adults, specifically through thyroid-hormone-mediated pathways, is a promising therapeutic target for obesity.

UR - http://www.scopus.com/inward/record.url?scp=84886890587&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84886890587&partnerID=8YFLogxK

U2 - 10.1016/S2213-8587(13)70069-X

DO - 10.1016/S2213-8587(13)70069-X

M3 - Article

C2 - 24622373

AN - SCOPUS:84886890587

VL - 1

SP - 250

EP - 258

JO - The Lancet Diabetes and Endocrinology

JF - The Lancet Diabetes and Endocrinology

SN - 2213-8587

IS - 3

ER -