The role of surgical debulking in cancer of the uterine cervix

Roger A. Potish, Gordon O. Downey, Leon L. Adcock, Konald A. Prem, Leo B. Twiggs

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

From 1978 to 1985, 159 women with advanced cervical cancer received definitive radiation therapy following extraperitoneal surgical staging including pelvic lymph node dissection and periaortic lymph node sampling. Relapse-free survival was a strong function of peritoneal and nodal metastases but was independent of clinical stage. The 5-year relapse-free rate fell from 86% in women without pelvic node metastases to 0% in those with unresectable pelvic node metastases. Women with microscopically positive pelvic node metastases had virtually the same (56%) relapse-free rate as those with grossly positive but completely resected metastases (57%). The overall pelvic failure rate was 16.4% and was significantly higher in women with unresectable pelvic node metastases. Periaortic and peritoneal metastases substantially increased the probability of recurrence. Although histologic grade was prognostically significant, histopathologic category was not. Severe enteric morbidity occurred in 3.6% of patients treated solely to the pelvis and in 7.9% of patients treated to the pelvis and periaortics. Therapeutic implications of debulking pelvic node metastases are discussed.

Original languageEnglish
Pages (from-to)979-984
Number of pages6
JournalInternational journal of radiation oncology, biology, physics
Volume17
Issue number5
DOIs
StatePublished - Jan 1 1989
Externally publishedYes

Fingerprint

metastasis
Uterine Cervical Neoplasms
cancer
Neoplasm Metastasis
Recurrence
pelvis
lymphatic system
Pelvis
dissection
Lymph Node Excision
radiation therapy
grade
Radiotherapy
Lymph Nodes
sampling
Morbidity
Survival

Keywords

  • Cervix cancer
  • Lymph node metastases
  • Surgical debulking
  • Surgical staging

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Radiation

Cite this

The role of surgical debulking in cancer of the uterine cervix. / Potish, Roger A.; Downey, Gordon O.; Adcock, Leon L.; Prem, Konald A.; Twiggs, Leo B.

In: International journal of radiation oncology, biology, physics, Vol. 17, No. 5, 01.01.1989, p. 979-984.

Research output: Contribution to journalArticle

Potish, Roger A. ; Downey, Gordon O. ; Adcock, Leon L. ; Prem, Konald A. ; Twiggs, Leo B. / The role of surgical debulking in cancer of the uterine cervix. In: International journal of radiation oncology, biology, physics. 1989 ; Vol. 17, No. 5. pp. 979-984.
@article{24d8ace95436423e8fa6d9a3ab7ebfcb,
title = "The role of surgical debulking in cancer of the uterine cervix",
abstract = "From 1978 to 1985, 159 women with advanced cervical cancer received definitive radiation therapy following extraperitoneal surgical staging including pelvic lymph node dissection and periaortic lymph node sampling. Relapse-free survival was a strong function of peritoneal and nodal metastases but was independent of clinical stage. The 5-year relapse-free rate fell from 86{\%} in women without pelvic node metastases to 0{\%} in those with unresectable pelvic node metastases. Women with microscopically positive pelvic node metastases had virtually the same (56{\%}) relapse-free rate as those with grossly positive but completely resected metastases (57{\%}). The overall pelvic failure rate was 16.4{\%} and was significantly higher in women with unresectable pelvic node metastases. Periaortic and peritoneal metastases substantially increased the probability of recurrence. Although histologic grade was prognostically significant, histopathologic category was not. Severe enteric morbidity occurred in 3.6{\%} of patients treated solely to the pelvis and in 7.9{\%} of patients treated to the pelvis and periaortics. Therapeutic implications of debulking pelvic node metastases are discussed.",
keywords = "Cervix cancer, Lymph node metastases, Surgical debulking, Surgical staging",
author = "Potish, {Roger A.} and Downey, {Gordon O.} and Adcock, {Leon L.} and Prem, {Konald A.} and Twiggs, {Leo B.}",
year = "1989",
month = "1",
day = "1",
doi = "10.1016/0360-3016(89)90145-4",
language = "English",
volume = "17",
pages = "979--984",
journal = "International Journal of Radiation Oncology Biology Physics",
issn = "0360-3016",
publisher = "Elsevier Inc.",
number = "5",

}

TY - JOUR

T1 - The role of surgical debulking in cancer of the uterine cervix

AU - Potish, Roger A.

AU - Downey, Gordon O.

AU - Adcock, Leon L.

AU - Prem, Konald A.

AU - Twiggs, Leo B.

PY - 1989/1/1

Y1 - 1989/1/1

N2 - From 1978 to 1985, 159 women with advanced cervical cancer received definitive radiation therapy following extraperitoneal surgical staging including pelvic lymph node dissection and periaortic lymph node sampling. Relapse-free survival was a strong function of peritoneal and nodal metastases but was independent of clinical stage. The 5-year relapse-free rate fell from 86% in women without pelvic node metastases to 0% in those with unresectable pelvic node metastases. Women with microscopically positive pelvic node metastases had virtually the same (56%) relapse-free rate as those with grossly positive but completely resected metastases (57%). The overall pelvic failure rate was 16.4% and was significantly higher in women with unresectable pelvic node metastases. Periaortic and peritoneal metastases substantially increased the probability of recurrence. Although histologic grade was prognostically significant, histopathologic category was not. Severe enteric morbidity occurred in 3.6% of patients treated solely to the pelvis and in 7.9% of patients treated to the pelvis and periaortics. Therapeutic implications of debulking pelvic node metastases are discussed.

AB - From 1978 to 1985, 159 women with advanced cervical cancer received definitive radiation therapy following extraperitoneal surgical staging including pelvic lymph node dissection and periaortic lymph node sampling. Relapse-free survival was a strong function of peritoneal and nodal metastases but was independent of clinical stage. The 5-year relapse-free rate fell from 86% in women without pelvic node metastases to 0% in those with unresectable pelvic node metastases. Women with microscopically positive pelvic node metastases had virtually the same (56%) relapse-free rate as those with grossly positive but completely resected metastases (57%). The overall pelvic failure rate was 16.4% and was significantly higher in women with unresectable pelvic node metastases. Periaortic and peritoneal metastases substantially increased the probability of recurrence. Although histologic grade was prognostically significant, histopathologic category was not. Severe enteric morbidity occurred in 3.6% of patients treated solely to the pelvis and in 7.9% of patients treated to the pelvis and periaortics. Therapeutic implications of debulking pelvic node metastases are discussed.

KW - Cervix cancer

KW - Lymph node metastases

KW - Surgical debulking

KW - Surgical staging

UR - http://www.scopus.com/inward/record.url?scp=0024462669&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024462669&partnerID=8YFLogxK

U2 - 10.1016/0360-3016(89)90145-4

DO - 10.1016/0360-3016(89)90145-4

M3 - Article

VL - 17

SP - 979

EP - 984

JO - International Journal of Radiation Oncology Biology Physics

JF - International Journal of Radiation Oncology Biology Physics

SN - 0360-3016

IS - 5

ER -