The role of steroids in the management of metastatic carcinoma to the brain: A pilot prospective trial

A. H. Wolfson, S. M. Snodgrass, J. G. Schwade, A. M. Markoe, H. Landy, L. G. Feun, K. S. Sridhar, A. H. Brandon, M. Rodriguez, P. V. Houdek

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

This prospective study attempted to evaluate the indications for glucocorticoids which are commonly given to patients with brain metastases. Twelve patients with histologically confirmed malignancies and radiographically documented brain metastases were enrolled. Patients were scored for general performance status and neurologic function class. All subjects were given high-dose dexamethasone (HDD) for 48 hours and then randomized to receive either intermediate-dose dexamethasone (IDD) or no steroids with cranial radiotherapy. Of these 12 study patients, 3 achieved a complete response, 1 partial response, and 8 nonresponses to HDD. Seven patients had IDD, while five received no IDD. Although a small sample size prevented any statistical analysis, this study does suggest that the place for using glucocorticoids in treating patients with metastatic carcinoma to the brain remains uncertain and should be evaluated in a cooperative prospective trial.

Original languageEnglish (US)
Pages (from-to)234-238
Number of pages5
JournalAmerican Journal of Clinical Oncology: Cancer Clinical Trials
Volume17
Issue number3
DOIs
StatePublished - Jan 1 1994

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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