The role of smooth muscle cells in the pathophysiology of pelvic organ prolapse

Shanshan Mei; Ming Ye; Laura Gil; Jianping Zhang; Yanping Zhang; Keith Candiotti; Peter Takacs

doi:10.1097/SPV.0b013e31829ff74d

The role of smooth muscle cells in the pathophysiology of pelvic organ prolapse

Shanshan Mei, Ming Ye, Laura Gil, Jianping Zhang, Yanping Zhang, Keith Candiotti, Peter Takacs

Anesthesiology

Research output: Contribution to journal › Review article › peer-review

4 Scopus citations

Abstract

Pelvic organ prolapse (POP) is a prevalent and disabling condition. The pathophysiology of prolapse is multifactorial, and no single mechanism adequately explains all aspects of its development. The pathophysiology of POP is complex and incompletely understood. Smooth muscle (SM), an integral part of the vaginal wall and endopelvic structures that support the pelvic viscera, has also been implicated in the pathophysiology of POP. In this article, we review the role of smooth muscle cells (SMC) in the pathophysiology of POP, also addressing the anatomy of SM in pelvic floor, morphometric analysis, biomechanical properties, and potential mechanisms.

Original language	English (US)
Pages (from-to)	254-259
Number of pages	6
Journal	Female Pelvic Medicine and Reconstructive Surgery
Volume	19
Issue number	5
DOIs	https://doi.org/10.1097/SPV.0b013e31829ff74d
State	Published - Jan 1 2013

Keywords

Pathophysiology
Pelvic organ prolapse
Smooth muscle cells

ASJC Scopus subject areas

Obstetrics and Gynecology
Surgery
Urology

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AU - Gil, Laura

AU - Zhang, Jianping

AU - Zhang, Yanping

AU - Candiotti, Keith

AU - Takacs, Peter

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AB - Pelvic organ prolapse (POP) is a prevalent and disabling condition. The pathophysiology of prolapse is multifactorial, and no single mechanism adequately explains all aspects of its development. The pathophysiology of POP is complex and incompletely understood. Smooth muscle (SM), an integral part of the vaginal wall and endopelvic structures that support the pelvic viscera, has also been implicated in the pathophysiology of POP. In this article, we review the role of smooth muscle cells (SMC) in the pathophysiology of POP, also addressing the anatomy of SM in pelvic floor, morphometric analysis, biomechanical properties, and potential mechanisms.

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