TY - JOUR
T1 - The role of smooth muscle cells in the pathophysiology of pelvic organ prolapse
AU - Mei, Shanshan
AU - Ye, Ming
AU - Gil, Laura
AU - Zhang, Jianping
AU - Zhang, Yanping
AU - Candiotti, Keith
AU - Takacs, Peter
PY - 2013/1/1
Y1 - 2013/1/1
N2 - Pelvic organ prolapse (POP) is a prevalent and disabling condition. The pathophysiology of prolapse is multifactorial, and no single mechanism adequately explains all aspects of its development. The pathophysiology of POP is complex and incompletely understood. Smooth muscle (SM), an integral part of the vaginal wall and endopelvic structures that support the pelvic viscera, has also been implicated in the pathophysiology of POP. In this article, we review the role of smooth muscle cells (SMC) in the pathophysiology of POP, also addressing the anatomy of SM in pelvic floor, morphometric analysis, biomechanical properties, and potential mechanisms.
AB - Pelvic organ prolapse (POP) is a prevalent and disabling condition. The pathophysiology of prolapse is multifactorial, and no single mechanism adequately explains all aspects of its development. The pathophysiology of POP is complex and incompletely understood. Smooth muscle (SM), an integral part of the vaginal wall and endopelvic structures that support the pelvic viscera, has also been implicated in the pathophysiology of POP. In this article, we review the role of smooth muscle cells (SMC) in the pathophysiology of POP, also addressing the anatomy of SM in pelvic floor, morphometric analysis, biomechanical properties, and potential mechanisms.
KW - Pathophysiology
KW - Pelvic organ prolapse
KW - Smooth muscle cells
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U2 - 10.1097/SPV.0b013e31829ff74d
DO - 10.1097/SPV.0b013e31829ff74d
M3 - Review article
C2 - 23982572
AN - SCOPUS:84884517264
VL - 19
SP - 254
EP - 259
JO - Female Pelvic Medicine and Reconstructive Surgery
JF - Female Pelvic Medicine and Reconstructive Surgery
SN - 2151-8378
IS - 5
ER -