The Role of Polyphenols in Rosacea Treatment: A Systematic Review

Suzana Saric, Ashley K. Clark, Raja K. Sivamani, Peter A. Lio, Hadar A. Lev-Tov

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Objectives: Various treatment options are available for the management of rosacea symptoms such as facial erythema, telangiectasia, papules and pustules, burning, stinging, and itching. Botanical therapies are commonly used to treat the symptoms. The objective of this review is to evaluate the use of polyphenols in rosacea treatment. Design: PubMed, Embase, Biosis, Web of Knowledge, and Scopus databases were systematically searched for clinical studies evaluating polyphenols in the management of rosacea. Results: Of 814 citations, 6 met the inclusion criteria. The studies evaluated licochalcone (n = 2), silymarin (n = 2), Crysanthellum indicum extract (n = 1), and quassia extract (n = 1). The studies only evaluated topical formations of stated polyphenols. Main results were summarized. Conclusions: There is evidence that polyphenols may be beneficial for the treatment of rosacea symptoms. Polyphenols appear to be most effective at reducing facial erythema and papule and pustule counts. However, studies included have significant methodological limitations and therefore large-scale, randomized, placebo-controlled trials are warranted to further assess the efficacy and safety of polyphenols in the treatment of rosacea.

Original languageEnglish (US)
Pages (from-to)920-929
Number of pages10
JournalJournal of Alternative and Complementary Medicine
Volume23
Issue number12
DOIs
StatePublished - Dec 2017

Keywords

  • facial erythema
  • licochalcone
  • polyphenols
  • rosacea
  • silymarin
  • treatment

ASJC Scopus subject areas

  • Complementary and alternative medicine

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