The role of peptides in affective disorders: A review

Arthur J. Prange, James C. Garbutt, Peter T. Loosen, Garth Bissette, Charles B. Nemeroff

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


This chapter reviews the role of peptides in affective disorders. The chapter focuses on the role of peptides to fulfil endocrine roles, thus, the chapter describes psychoendocrinology—that is, the relationships between mental function and endocrine function, but only to a special area of psychoendocrinology. Like psychoendocrinology, the affective disorders are subject to division into depression (and its subtypes) and mania. The use of peptide hormones has contributed to the advancement of psychoendocrinology in several ways. Having been isolated, identified, and synthesized, many are now available for administration. These and other peptide hormones, which are not yet available for administration, can be assayed in tissues with satisfactory specificity and sensitivity. The finding regarding alterations in the concentration of a peptide in the body fluid of patients with affective disorders demonstrates that in depressed patients SRIF levels are diminished in CSF; in manic patients they are normal

Original languageEnglish (US)
Pages (from-to)235-247
Number of pages13
JournalProgress in brain research
Issue numberC
StatePublished - Jan 1987
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)


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