Abstract
ATP has been shown to be a taste bud afferent transmitter, but the cells responsible for, and the mechanism of, its release have not been identified. Using CHO cells expressing high-affinity neurotransmitter receptors as biosensors, we show that gustatory stimuli cause receptor cells to secrete ATP through pannexin 1 hemichannels in mouse taste buds. ATP further stimulates other taste cells to release a second transmitter, serotonin. These results provide a mechanism to link intracellular Ca2+ release during taste transduction to secretion of afferent transmitter, ATP, from receptor cells. They also indicate a route for cell-cell communication and signal processing within the taste bud.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 6436-6441 |
| Number of pages | 6 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Volume | 104 |
| Issue number | 15 |
| DOIs | |
| State | Published - Apr 10 2007 |
Keywords
- Afferent
- Gustation
- Serotonin
- Synapses
ASJC Scopus subject areas
- Genetics
- General
Fingerprint Dive into the research topics of 'The role of pannexin 1 hemichannels in ATP release and cell-cell communication in mouse taste buds'. Together they form a unique fingerprint.
Cite this
Huang, Y. J., Maruyama, Y., Dvoryanchikov, G., Pereira, E., Chaudhari, N., & Roper, S. D. (2007). The role of pannexin 1 hemichannels in ATP release and cell-cell communication in mouse taste buds. Proceedings of the National Academy of Sciences of the United States of America, 104(15), 6436-6441. https://doi.org/10.1073/pnas.0611280104