The role of P-cadherin in skin biology and skin pathology: lessons from the hair follicle

Liat Samuelov, Eli Sprecher, Ralf Paus

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations


Adherens junctions (AJs) are one of the major intercellular junctions in various epithelia including the epidermis and the follicular epithelium. AJs connect the cell surface to the actin cytoskeleton and comprise classic transmembrane cadherins, such as P-cadherin, armadillo family proteins, and actin microfilaments. Loss-of-function mutations in CDH3, which encodes P-cadherin, result in two allelic autosomal recessive disorders: hypotrichosis with juvenile macular dystrophy (HJMD) and ectodermal dysplasia, ectrodactyly, and macular dystrophy (EEM) syndromes. Both syndromes feature sparse hair heralding progressive macular dystrophy. EEM syndrome is characterized in addition by ectodermal and limb defects. Recent studies have demonstrated that, together with its involvement in cell-cell adhesion, P-cadherin plays a crucial role in regulating cell signaling, malignant transformation, and other major intercellular processes. Here, we review the roles of P-cadherin in skin and hair biology, with emphasize on human hair growth, cycling and pigmentation.

Original languageEnglish (US)
Pages (from-to)761-771
Number of pages11
JournalCell and Tissue Research
Issue number3
StatePublished - Jun 4 2015
Externally publishedYes


  • EEM syndrome
  • HJMD syndrome
  • P-cadherin
  • Wnt signaling
  • β-Catenin

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology
  • Cell Biology


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