The Role of Oxidative Stress-Induced Epigenetic Alterations in Amyloid-β Production in Alzheimer's Disease

Li Zuo, Benjamin T. Hemmelgarn, Chia Chen Chuang, Thomas Best

Research output: Contribution to journalReview article

42 Citations (Scopus)

Abstract

An increasing number of studies have proposed a strong correlation between reactive oxygen species (ROS)-induced oxidative stress (OS) and the pathogenesis of Alzheimer's disease (AD). With over five million people diagnosed in the United States alone, AD is the most common type of dementia worldwide. AD includes progressive neurodegeneration, followed by memory loss and reduced cognitive ability. Characterized by the formation of amyloid-beta (Aβ) plaques as a hallmark, the connection between ROS and AD is compelling. Analyzing the ROS response of essential proteins in the amyloidogenic pathway, such as amyloid-beta precursor protein (APP) and beta-secretase (BACE1), along with influential signaling programs of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and c-Jun N-terminal kinase (JNK), has helped visualize the path between OS and Aβ overproduction. In this review, attention will be paid to significant advances in the area of OS, epigenetics, and their influence on Aβ plaque assembly. Additionally, we aim to discuss available treatment options for AD that include antioxidant supplements, Asian traditional medicines, metal-protein-attenuating compounds, and histone modifying inhibitors.

Original languageEnglish (US)
Article number604658
JournalOxidative Medicine and Cellular Longevity
Volume2015
DOIs
StatePublished - Jan 1 2015
Externally publishedYes

Fingerprint

Oxidative stress
Amyloid
Epigenomics
Alzheimer Disease
Oxidative Stress
Reactive Oxygen Species
Amyloidogenic Proteins
Amyloid Precursor Protein Secretases
Aptitude
JNK Mitogen-Activated Protein Kinases
Amyloid beta-Protein Precursor
Memory Disorders
Traditional Medicine
Histones
Medicine
Dementia
Proteins
B-Lymphocytes
Antioxidants
Metals

ASJC Scopus subject areas

  • Biochemistry
  • Aging
  • Cell Biology

Cite this

The Role of Oxidative Stress-Induced Epigenetic Alterations in Amyloid-β Production in Alzheimer's Disease. / Zuo, Li; Hemmelgarn, Benjamin T.; Chuang, Chia Chen; Best, Thomas.

In: Oxidative Medicine and Cellular Longevity, Vol. 2015, 604658, 01.01.2015.

Research output: Contribution to journalReview article

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