The role of osteopontin in the development of albuminuria

Johan Lorenzen, Rajshree Shah, Alisha Biser, Serban A. Staicu, Thiruvur Niranjan, Ana Maria Garcia, Antje Gruenwald, David Thomas, Ibrahim F. Shatat, Katarine Supe, Robert P. Woroniecki, Katalin Susztak

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

Several gene array studies have suggested that osteopontin (Opn) expression strongly correlates with albuminuria and glomerular disease. Urinary Opn concentration and kidney Opn immunoreactivity were found to be increased in patients with steroid-sensitive nephrotic syndrome. In addition, renal Opn mRNA was increased in the Ins2Akita mouse model of type 1 diabetic nephropathy, in the LPS-induced albuminuria model, and in glomeruli of puromycin aminonucleotide-induced nephrotic rats. Opn knockout mice did not develop albuminuria in response to LPS injection, and Opn knockout mice were protected from diabetes-induced albuminuria and mesangial expansion. In the glomerulus, Opn immunostaining was increased specifically in podocytes. Treatment of podocytes with recombinant Opn activated the NF-κB pathway, increased expression of urokinase plasminogen activator and matrix metalloproteinases 2 and 9, and increased podocyte motility. Taken together, these results indicate that Opn plays an important role in the development of albuminuria, possibly by modulating podocyte signaling and motility.

Original languageEnglish
Pages (from-to)884-890
Number of pages7
JournalJournal of the American Society of Nephrology
Volume19
Issue number5
DOIs
StatePublished - May 1 2008
Externally publishedYes

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Osteopontin
Albuminuria
Podocytes
Knockout Mice
Kidney
Puromycin
Plasminogen Activators
Matrix Metalloproteinase 2
Matrix Metalloproteinase 9
Urokinase-Type Plasminogen Activator
Nephrotic Syndrome
Diabetic Nephropathies
Steroids
Messenger RNA
Injections

ASJC Scopus subject areas

  • Nephrology
  • Medicine(all)

Cite this

Lorenzen, J., Shah, R., Biser, A., Staicu, S. A., Niranjan, T., Garcia, A. M., ... Susztak, K. (2008). The role of osteopontin in the development of albuminuria. Journal of the American Society of Nephrology, 19(5), 884-890. https://doi.org/10.1681/ASN.2007040486

The role of osteopontin in the development of albuminuria. / Lorenzen, Johan; Shah, Rajshree; Biser, Alisha; Staicu, Serban A.; Niranjan, Thiruvur; Garcia, Ana Maria; Gruenwald, Antje; Thomas, David; Shatat, Ibrahim F.; Supe, Katarine; Woroniecki, Robert P.; Susztak, Katalin.

In: Journal of the American Society of Nephrology, Vol. 19, No. 5, 01.05.2008, p. 884-890.

Research output: Contribution to journalArticle

Lorenzen, J, Shah, R, Biser, A, Staicu, SA, Niranjan, T, Garcia, AM, Gruenwald, A, Thomas, D, Shatat, IF, Supe, K, Woroniecki, RP & Susztak, K 2008, 'The role of osteopontin in the development of albuminuria', Journal of the American Society of Nephrology, vol. 19, no. 5, pp. 884-890. https://doi.org/10.1681/ASN.2007040486
Lorenzen J, Shah R, Biser A, Staicu SA, Niranjan T, Garcia AM et al. The role of osteopontin in the development of albuminuria. Journal of the American Society of Nephrology. 2008 May 1;19(5):884-890. https://doi.org/10.1681/ASN.2007040486
Lorenzen, Johan ; Shah, Rajshree ; Biser, Alisha ; Staicu, Serban A. ; Niranjan, Thiruvur ; Garcia, Ana Maria ; Gruenwald, Antje ; Thomas, David ; Shatat, Ibrahim F. ; Supe, Katarine ; Woroniecki, Robert P. ; Susztak, Katalin. / The role of osteopontin in the development of albuminuria. In: Journal of the American Society of Nephrology. 2008 ; Vol. 19, No. 5. pp. 884-890.
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