The role of microtubule‐associated protein 2 (MAP‐2) in neuronal growth, plasticity, and degeneration

G. V.W. Johnson, R. S. Jope

Research output: Contribution to journalReview article

248 Scopus citations

Abstract

Microtubule associated protein 2 (MAP-2) historically has been perceived primarily as a static, structural protein, necessary along with other cytoskeletal proteins to maintain neuroarchitecture but somewhat removed from the 'mainstream' of neuronal response mechanisms. Quite to the contrary, MAP- 2 is exquisitely sensitive to many inputs and recent investigations have revealed dynamic functions for MAP-2 in the growth, differentiation, and plasticity of neurons, with key roles in neuronal responses to growth factors, neurotransmitters, synaptic activity, and neurotoxins. These discoveries indicate that modification and rearrangement of MAP-2 is an early obligatory step in many processes which modify neuronal function.

Original languageEnglish (US)
Pages (from-to)505-512
Number of pages8
JournalJournal of Neuroscience Research
Volume33
Issue number4
DOIs
StatePublished - Dec 1992
Externally publishedYes

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

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