TY - JOUR
T1 - The role of microtubule‐associated protein 2 (MAP‐2) in neuronal growth, plasticity, and degeneration
AU - Johnson, G. V.W.
AU - Jope, R. S.
N1 - Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 1992/12
Y1 - 1992/12
N2 - Microtubule associated protein 2 (MAP-2) historically has been perceived primarily as a static, structural protein, necessary along with other cytoskeletal proteins to maintain neuroarchitecture but somewhat removed from the 'mainstream' of neuronal response mechanisms. Quite to the contrary, MAP- 2 is exquisitely sensitive to many inputs and recent investigations have revealed dynamic functions for MAP-2 in the growth, differentiation, and plasticity of neurons, with key roles in neuronal responses to growth factors, neurotransmitters, synaptic activity, and neurotoxins. These discoveries indicate that modification and rearrangement of MAP-2 is an early obligatory step in many processes which modify neuronal function.
AB - Microtubule associated protein 2 (MAP-2) historically has been perceived primarily as a static, structural protein, necessary along with other cytoskeletal proteins to maintain neuroarchitecture but somewhat removed from the 'mainstream' of neuronal response mechanisms. Quite to the contrary, MAP- 2 is exquisitely sensitive to many inputs and recent investigations have revealed dynamic functions for MAP-2 in the growth, differentiation, and plasticity of neurons, with key roles in neuronal responses to growth factors, neurotransmitters, synaptic activity, and neurotoxins. These discoveries indicate that modification and rearrangement of MAP-2 is an early obligatory step in many processes which modify neuronal function.
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U2 - 10.1002/jnr.490330402
DO - 10.1002/jnr.490330402
M3 - Review article
C2 - 1484385
AN - SCOPUS:0026472560
VL - 33
SP - 505
EP - 512
JO - Journal of Neuroscience Research
JF - Journal of Neuroscience Research
SN - 0360-4012
IS - 4
ER -