The role of microbial flora on the ocular surface

Darlene Miller, Alfonso Iovieno

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

PURPOSE OF REVIEW: Presence and interplay of microbial flora at the ocular surface reveal dynamic and evolving interactions with implications for both ocular surface health and disease. Data in this area are scarce or non-existent. The purpose of this review is to provide a snapshot of new and emerging developments in this area over the last 12 months. RECENT FINDINGS: Recent findings signal potential roles for ocular surface microbial flora in both the preservation and extension of ocular surface health and in the initiation of new or escalation of common surface disorders. Contributions range from priming surface epithelial immune cells to regulating mucin composition and production. Other findings explore the emergent role of ocular microbial flora cross talk with pattern recognition receptors to protect and strengthen local and adaptive mucosal immunity while preserving vision. SUMMARY: Deciphering the functional role of microbial communities at the ocular surface could bring new insights into and clarify the epidemiology and pathology of ocular surface dynamics in health and disease.

Original languageEnglish
Pages (from-to)466-470
Number of pages5
JournalCurrent Opinion in Allergy and Clinical Immunology
Volume9
Issue number5
DOIs
StatePublished - Oct 1 2009

Fingerprint

Health
Pattern Recognition Receptors
Mucosal Immunity
Adaptive Immunity
Mucins
Epidemiology
Epithelial Cells
Pathology

Keywords

  • Microbial flora
  • Ocular surface
  • Toll-like receptor

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

The role of microbial flora on the ocular surface. / Miller, Darlene; Iovieno, Alfonso.

In: Current Opinion in Allergy and Clinical Immunology, Vol. 9, No. 5, 01.10.2009, p. 466-470.

Research output: Contribution to journalArticle

@article{35b00ce1098f47508bd3eb79a8b85912,
title = "The role of microbial flora on the ocular surface",
abstract = "PURPOSE OF REVIEW: Presence and interplay of microbial flora at the ocular surface reveal dynamic and evolving interactions with implications for both ocular surface health and disease. Data in this area are scarce or non-existent. The purpose of this review is to provide a snapshot of new and emerging developments in this area over the last 12 months. RECENT FINDINGS: Recent findings signal potential roles for ocular surface microbial flora in both the preservation and extension of ocular surface health and in the initiation of new or escalation of common surface disorders. Contributions range from priming surface epithelial immune cells to regulating mucin composition and production. Other findings explore the emergent role of ocular microbial flora cross talk with pattern recognition receptors to protect and strengthen local and adaptive mucosal immunity while preserving vision. SUMMARY: Deciphering the functional role of microbial communities at the ocular surface could bring new insights into and clarify the epidemiology and pathology of ocular surface dynamics in health and disease.",
keywords = "Microbial flora, Ocular surface, Toll-like receptor",
author = "Darlene Miller and Alfonso Iovieno",
year = "2009",
month = "10",
day = "1",
doi = "10.1097/ACI.0b013e3283303e1b",
language = "English",
volume = "9",
pages = "466--470",
journal = "Current Opinion in Allergy and Clinical Immunology",
issn = "1528-4050",
publisher = "Lippincott Williams and Wilkins",
number = "5",

}

TY - JOUR

T1 - The role of microbial flora on the ocular surface

AU - Miller, Darlene

AU - Iovieno, Alfonso

PY - 2009/10/1

Y1 - 2009/10/1

N2 - PURPOSE OF REVIEW: Presence and interplay of microbial flora at the ocular surface reveal dynamic and evolving interactions with implications for both ocular surface health and disease. Data in this area are scarce or non-existent. The purpose of this review is to provide a snapshot of new and emerging developments in this area over the last 12 months. RECENT FINDINGS: Recent findings signal potential roles for ocular surface microbial flora in both the preservation and extension of ocular surface health and in the initiation of new or escalation of common surface disorders. Contributions range from priming surface epithelial immune cells to regulating mucin composition and production. Other findings explore the emergent role of ocular microbial flora cross talk with pattern recognition receptors to protect and strengthen local and adaptive mucosal immunity while preserving vision. SUMMARY: Deciphering the functional role of microbial communities at the ocular surface could bring new insights into and clarify the epidemiology and pathology of ocular surface dynamics in health and disease.

AB - PURPOSE OF REVIEW: Presence and interplay of microbial flora at the ocular surface reveal dynamic and evolving interactions with implications for both ocular surface health and disease. Data in this area are scarce or non-existent. The purpose of this review is to provide a snapshot of new and emerging developments in this area over the last 12 months. RECENT FINDINGS: Recent findings signal potential roles for ocular surface microbial flora in both the preservation and extension of ocular surface health and in the initiation of new or escalation of common surface disorders. Contributions range from priming surface epithelial immune cells to regulating mucin composition and production. Other findings explore the emergent role of ocular microbial flora cross talk with pattern recognition receptors to protect and strengthen local and adaptive mucosal immunity while preserving vision. SUMMARY: Deciphering the functional role of microbial communities at the ocular surface could bring new insights into and clarify the epidemiology and pathology of ocular surface dynamics in health and disease.

KW - Microbial flora

KW - Ocular surface

KW - Toll-like receptor

UR - http://www.scopus.com/inward/record.url?scp=69749091746&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=69749091746&partnerID=8YFLogxK

U2 - 10.1097/ACI.0b013e3283303e1b

DO - 10.1097/ACI.0b013e3283303e1b

M3 - Article

C2 - 19620859

AN - SCOPUS:69749091746

VL - 9

SP - 466

EP - 470

JO - Current Opinion in Allergy and Clinical Immunology

JF - Current Opinion in Allergy and Clinical Immunology

SN - 1528-4050

IS - 5

ER -