The role of matricellular proteins and tissue stiffness in breast cancer: A systematic review

Sirio Fiorino, Salomone Di Saverio, Paolo Leandri, Andrea Tura, Chiara Birtolo, Mauro Silingardi, Dario De Biase, Eli Avisar

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

Malignancies consist not only of cancerous and nonmalignant cells, but also of additional elements, as extracellular matrix. The aim of this review is to summarize meta-analyses, describing breast tissue stiffness and risk of breast carcinoma (BC) assessing the potential relationship between matricellular proteins (MPs) and survival. A systematic computer-based search of published articles, according to PRISMA statement, was conducted through Ovid interface. Mammographic density and tissue stiffness are associated with the risk of BC development, suggesting that MPs may influence BC prognosis. No definitive conclusions are available and additional researches are required to definitively clarify the role of each MP, mammographic density and stiffness in BC development and the mechanisms involved in the onset of this malignancy.

Original languageEnglish (US)
Pages (from-to)1601-1627
Number of pages27
JournalFuture Oncology
Volume14
Issue number16
DOIs
StatePublished - Jul 1 2018

Fingerprint

Breast Neoplasms
Proteins
Extracellular Matrix
Meta-Analysis
Neoplasms
Breast
Research
Breast Density

Keywords

  • breast cancer
  • matricellular proteins
  • osteopontin
  • periostin
  • SPARC
  • stiffness

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Fiorino, S., Di Saverio, S., Leandri, P., Tura, A., Birtolo, C., Silingardi, M., ... Avisar, E. (2018). The role of matricellular proteins and tissue stiffness in breast cancer: A systematic review. Future Oncology, 14(16), 1601-1627. https://doi.org/10.2217/fon-2017-0510

The role of matricellular proteins and tissue stiffness in breast cancer : A systematic review. / Fiorino, Sirio; Di Saverio, Salomone; Leandri, Paolo; Tura, Andrea; Birtolo, Chiara; Silingardi, Mauro; De Biase, Dario; Avisar, Eli.

In: Future Oncology, Vol. 14, No. 16, 01.07.2018, p. 1601-1627.

Research output: Contribution to journalReview article

Fiorino, S, Di Saverio, S, Leandri, P, Tura, A, Birtolo, C, Silingardi, M, De Biase, D & Avisar, E 2018, 'The role of matricellular proteins and tissue stiffness in breast cancer: A systematic review', Future Oncology, vol. 14, no. 16, pp. 1601-1627. https://doi.org/10.2217/fon-2017-0510
Fiorino S, Di Saverio S, Leandri P, Tura A, Birtolo C, Silingardi M et al. The role of matricellular proteins and tissue stiffness in breast cancer: A systematic review. Future Oncology. 2018 Jul 1;14(16):1601-1627. https://doi.org/10.2217/fon-2017-0510
Fiorino, Sirio ; Di Saverio, Salomone ; Leandri, Paolo ; Tura, Andrea ; Birtolo, Chiara ; Silingardi, Mauro ; De Biase, Dario ; Avisar, Eli. / The role of matricellular proteins and tissue stiffness in breast cancer : A systematic review. In: Future Oncology. 2018 ; Vol. 14, No. 16. pp. 1601-1627.
@article{2ccf10cfb6d248099501c1c07db2f8a7,
title = "The role of matricellular proteins and tissue stiffness in breast cancer: A systematic review",
abstract = "Malignancies consist not only of cancerous and nonmalignant cells, but also of additional elements, as extracellular matrix. The aim of this review is to summarize meta-analyses, describing breast tissue stiffness and risk of breast carcinoma (BC) assessing the potential relationship between matricellular proteins (MPs) and survival. A systematic computer-based search of published articles, according to PRISMA statement, was conducted through Ovid interface. Mammographic density and tissue stiffness are associated with the risk of BC development, suggesting that MPs may influence BC prognosis. No definitive conclusions are available and additional researches are required to definitively clarify the role of each MP, mammographic density and stiffness in BC development and the mechanisms involved in the onset of this malignancy.",
keywords = "breast cancer, matricellular proteins, osteopontin, periostin, SPARC, stiffness",
author = "Sirio Fiorino and {Di Saverio}, Salomone and Paolo Leandri and Andrea Tura and Chiara Birtolo and Mauro Silingardi and {De Biase}, Dario and Eli Avisar",
year = "2018",
month = "7",
day = "1",
doi = "10.2217/fon-2017-0510",
language = "English (US)",
volume = "14",
pages = "1601--1627",
journal = "Future Oncology",
issn = "1479-6694",
publisher = "Future Medicine Ltd.",
number = "16",

}

TY - JOUR

T1 - The role of matricellular proteins and tissue stiffness in breast cancer

T2 - A systematic review

AU - Fiorino, Sirio

AU - Di Saverio, Salomone

AU - Leandri, Paolo

AU - Tura, Andrea

AU - Birtolo, Chiara

AU - Silingardi, Mauro

AU - De Biase, Dario

AU - Avisar, Eli

PY - 2018/7/1

Y1 - 2018/7/1

N2 - Malignancies consist not only of cancerous and nonmalignant cells, but also of additional elements, as extracellular matrix. The aim of this review is to summarize meta-analyses, describing breast tissue stiffness and risk of breast carcinoma (BC) assessing the potential relationship between matricellular proteins (MPs) and survival. A systematic computer-based search of published articles, according to PRISMA statement, was conducted through Ovid interface. Mammographic density and tissue stiffness are associated with the risk of BC development, suggesting that MPs may influence BC prognosis. No definitive conclusions are available and additional researches are required to definitively clarify the role of each MP, mammographic density and stiffness in BC development and the mechanisms involved in the onset of this malignancy.

AB - Malignancies consist not only of cancerous and nonmalignant cells, but also of additional elements, as extracellular matrix. The aim of this review is to summarize meta-analyses, describing breast tissue stiffness and risk of breast carcinoma (BC) assessing the potential relationship between matricellular proteins (MPs) and survival. A systematic computer-based search of published articles, according to PRISMA statement, was conducted through Ovid interface. Mammographic density and tissue stiffness are associated with the risk of BC development, suggesting that MPs may influence BC prognosis. No definitive conclusions are available and additional researches are required to definitively clarify the role of each MP, mammographic density and stiffness in BC development and the mechanisms involved in the onset of this malignancy.

KW - breast cancer

KW - matricellular proteins

KW - osteopontin

KW - periostin

KW - SPARC

KW - stiffness

UR - http://www.scopus.com/inward/record.url?scp=85049834882&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85049834882&partnerID=8YFLogxK

U2 - 10.2217/fon-2017-0510

DO - 10.2217/fon-2017-0510

M3 - Review article

C2 - 29939077

AN - SCOPUS:85049834882

VL - 14

SP - 1601

EP - 1627

JO - Future Oncology

JF - Future Oncology

SN - 1479-6694

IS - 16

ER -