The role of matricellular proteins and tissue stiffness in breast cancer: A systematic review

Sirio Fiorino, Salomone Di Saverio, Paolo Leandri, Andrea Tura, Chiara Birtolo, Mauro Silingardi, Dario De Biase, Eli Avisar

Research output: Contribution to journalReview article

4 Scopus citations

Abstract

Malignancies consist not only of cancerous and nonmalignant cells, but also of additional elements, as extracellular matrix. The aim of this review is to summarize meta-analyses, describing breast tissue stiffness and risk of breast carcinoma (BC) assessing the potential relationship between matricellular proteins (MPs) and survival. A systematic computer-based search of published articles, according to PRISMA statement, was conducted through Ovid interface. Mammographic density and tissue stiffness are associated with the risk of BC development, suggesting that MPs may influence BC prognosis. No definitive conclusions are available and additional researches are required to definitively clarify the role of each MP, mammographic density and stiffness in BC development and the mechanisms involved in the onset of this malignancy.

Original languageEnglish (US)
Pages (from-to)1601-1627
Number of pages27
JournalFuture Oncology
Volume14
Issue number16
DOIs
StatePublished - Jul 1 2018

Keywords

  • breast cancer
  • matricellular proteins
  • osteopontin
  • periostin
  • SPARC
  • stiffness

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Fiorino, S., Di Saverio, S., Leandri, P., Tura, A., Birtolo, C., Silingardi, M., De Biase, D., & Avisar, E. (2018). The role of matricellular proteins and tissue stiffness in breast cancer: A systematic review. Future Oncology, 14(16), 1601-1627. https://doi.org/10.2217/fon-2017-0510