The role of mast cells after solid organ transplantation

Jama Jahanyar, Michael M. Koerner, Matthias Loebe, Keith A. Youker, Guillermo Torre-Amione, George P. Noon

Research output: Contribution to journalReview article

17 Scopus citations

Abstract

Mast cells are best known as primary responders in allergic reactions, including anaphylaxis and asthma. However, recent studies have shown that mast cells are functionally diverse cells with immunoregulatory properties that influence both the innate and adaptive immunities. Mast cells are capable of producing an array of both proinflammatory and anti-inflammatory mediators, acting as antigen-presenting cells, and expressing a spectrum of costimulatory molecules. Moreover, mast cells seem to confer a certain degree of immune privilege to tissues in concert with T-regulatory cells and are essential players in fibrotic conditions. The following review of the literature serves to further define the role of mast cells in the immunologic reactions affecting transplanted solid organ grafts.

Original languageEnglish (US)
Pages (from-to)1365-1371
Number of pages7
JournalTransplantation
Volume85
Issue number10
DOIs
StatePublished - May 27 2008
Externally publishedYes

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Keywords

  • Allograft tolerance
  • Fibrosis
  • Mast cells
  • Organ rejection

ASJC Scopus subject areas

  • Transplantation

Cite this

Jahanyar, J., Koerner, M. M., Loebe, M., Youker, K. A., Torre-Amione, G., & Noon, G. P. (2008). The role of mast cells after solid organ transplantation. Transplantation, 85(10), 1365-1371. https://doi.org/10.1097/TP.0b013e31816fc0a3