The role of leukotrienes in allergen-induced late responses in allergic sheep

W. M. Abraham

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Evidence has been presented that lipoxygenase products of arachidonic acid metabolism released during the early stages of allergic reactions play an important role in the subsequent development of late bronchial responses. Moreover, because of this, the activity of the lipoxygenase pathway and sensitivity to the products generated may be important factors that distinguish between dual and acute responders. We recognize that these studies were performed in an experimental animal model of allergic airway disease. If the same mechanisms that are active in sheep are proven active in humans, then pharmacologic modifications of the lipoxygenase pathway or its products (or both) may be important for the treatment of some forms of asthma.

Original languageEnglish
Pages (from-to)260-270
Number of pages11
JournalAnnals of the New York Academy of Sciences
Volume524
StatePublished - Jan 1 1988
Externally publishedYes

Fingerprint

Lipoxygenase
Leukotrienes
Allergens
Sheep
Arachidonate Lipoxygenases
Hypersensitivity
Asthma
Animal Models
Arachidonic Acid
Metabolism
Animals
Pathway
Animal Model

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

The role of leukotrienes in allergen-induced late responses in allergic sheep. / Abraham, W. M.

In: Annals of the New York Academy of Sciences, Vol. 524, 01.01.1988, p. 260-270.

Research output: Contribution to journalArticle

@article{384845c5ed024ff8abef3819bd370042,
title = "The role of leukotrienes in allergen-induced late responses in allergic sheep",
abstract = "Evidence has been presented that lipoxygenase products of arachidonic acid metabolism released during the early stages of allergic reactions play an important role in the subsequent development of late bronchial responses. Moreover, because of this, the activity of the lipoxygenase pathway and sensitivity to the products generated may be important factors that distinguish between dual and acute responders. We recognize that these studies were performed in an experimental animal model of allergic airway disease. If the same mechanisms that are active in sheep are proven active in humans, then pharmacologic modifications of the lipoxygenase pathway or its products (or both) may be important for the treatment of some forms of asthma.",
author = "Abraham, {W. M.}",
year = "1988",
month = "1",
day = "1",
language = "English",
volume = "524",
pages = "260--270",
journal = "Annals of the New York Academy of Sciences",
issn = "0077-8923",
publisher = "Wiley-Blackwell",

}

TY - JOUR

T1 - The role of leukotrienes in allergen-induced late responses in allergic sheep

AU - Abraham, W. M.

PY - 1988/1/1

Y1 - 1988/1/1

N2 - Evidence has been presented that lipoxygenase products of arachidonic acid metabolism released during the early stages of allergic reactions play an important role in the subsequent development of late bronchial responses. Moreover, because of this, the activity of the lipoxygenase pathway and sensitivity to the products generated may be important factors that distinguish between dual and acute responders. We recognize that these studies were performed in an experimental animal model of allergic airway disease. If the same mechanisms that are active in sheep are proven active in humans, then pharmacologic modifications of the lipoxygenase pathway or its products (or both) may be important for the treatment of some forms of asthma.

AB - Evidence has been presented that lipoxygenase products of arachidonic acid metabolism released during the early stages of allergic reactions play an important role in the subsequent development of late bronchial responses. Moreover, because of this, the activity of the lipoxygenase pathway and sensitivity to the products generated may be important factors that distinguish between dual and acute responders. We recognize that these studies were performed in an experimental animal model of allergic airway disease. If the same mechanisms that are active in sheep are proven active in humans, then pharmacologic modifications of the lipoxygenase pathway or its products (or both) may be important for the treatment of some forms of asthma.

UR - http://www.scopus.com/inward/record.url?scp=0023711805&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023711805&partnerID=8YFLogxK

M3 - Article

VL - 524

SP - 260

EP - 270

JO - Annals of the New York Academy of Sciences

JF - Annals of the New York Academy of Sciences

SN - 0077-8923

ER -