The role of KRAS mutations in resistance to EGFR inhibition in the treatment of cancer

Ariel Lopez-Chavez, Corey A. Carter, Giuseppe Giaccone

Research output: Contribution to journalReview article

28 Scopus citations

Abstract

The development of EGFR inhibitors has influenced the field of targeted therapeutics significantly. Unfortunately, the benefits of EGFR inhibitors are limited by several mechanisms of drug resistance, which include KRAS mutations. Mutations in this gene result in constitutive activation of the Ras/Raf/MEK/ERK pathway, with loss of EGFR signaling control, rendering inhibitors of EGFR ineffective. Several strategies are being developed to overcome this mechanism of resistance, including MEK inhibitors, Braf inhibitors, Hsp90 inhibitors, K-Ras-directed immunotherapy, mTOR inhibitors and several combination approaches.

Original languageEnglish (US)
Pages (from-to)1305-1314
Number of pages10
JournalCurrent Opinion in Investigational Drugs
Volume10
Issue number12
StatePublished - Dec 1 2009

Keywords

  • Colorectal cancer
  • EGFR
  • Erb-B1
  • K-Ras
  • KRAS
  • Lung cancer
  • Pancreatic cancer

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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