The role of interleukin-21 in HIV infection

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Interleukin (IL)-21 is one of a group of cytokines including IL-2, IL-4, IL-7, IL-9 and IL-15 whose receptor complexes share the common γ chain (γc). Secretion of IL-21 is restricted mainly to T follicular helper (TFH) CD4 T cell subset with contributions from Th17, natural killer (NK) T cells, but the effects of IL-21 are pleiotropic, owing to the broad cellular distribution of the IL-21 receptor. The role of IL-21 in sustaining and regulating T cell, B cell and NK cell responses during chronic viral infections has recently come into focus. This chapter reviews current knowledge about the biology of IL-21 in the context of HIV infection.

Original languageEnglish
Pages (from-to)173-180
Number of pages8
JournalCytokine and Growth Factor Reviews
Volume23
Issue number4-5
DOIs
StatePublished - Aug 1 2012

Fingerprint

HIV Infections
T-cells
Interleukin-21 Receptors
Interleukin-15 Receptors
Interleukin-9
Interleukin-7
Natural Killer T-Cells
T-Lymphocyte Subsets
Virus Diseases
Helper-Inducer T-Lymphocytes
Natural Killer Cells
Interleukin-4
Interleukin-2
B-Lymphocytes
Cells
interleukin-21
Cytokines
T-Lymphocytes

Keywords

  • HIV and IL-21
  • IL-21 and B cells
  • IL-21 and immunity
  • IL-21 and T cells
  • Immunomodulation by IL-21

ASJC Scopus subject areas

  • Immunology
  • Endocrinology, Diabetes and Metabolism
  • Immunology and Allergy
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

The role of interleukin-21 in HIV infection. / Pallikkuth, Suresh; Parmigiani, Anita; Pahwa, Savita G.

In: Cytokine and Growth Factor Reviews, Vol. 23, No. 4-5, 01.08.2012, p. 173-180.

Research output: Contribution to journalArticle

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