The role of interleukin-21 in HIV infection

Suresh Pallikkuth; Anita Parmigiani; Savita Pahwa

doi:10.1016/j.cytogfr.2012.05.004

The role of interleukin-21 in HIV infection

Suresh Pallikkuth, Anita Parmigiani, Savita Pahwa

Microbiology & Immunology

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Interleukin (IL)-21 is one of a group of cytokines including IL-2, IL-4, IL-7, IL-9 and IL-15 whose receptor complexes share the common γ chain (γ_c). Secretion of IL-21 is restricted mainly to T follicular helper (TFH) CD4 T cell subset with contributions from Th17, natural killer (NK) T cells, but the effects of IL-21 are pleiotropic, owing to the broad cellular distribution of the IL-21 receptor. The role of IL-21 in sustaining and regulating T cell, B cell and NK cell responses during chronic viral infections has recently come into focus. This chapter reviews current knowledge about the biology of IL-21 in the context of HIV infection.

Original language	English (US)
Pages (from-to)	173-180
Number of pages	8
Journal	Cytokine and Growth Factor Reviews
Volume	23
Issue number	4-5
DOIs	https://doi.org/10.1016/j.cytogfr.2012.05.004
State	Published - Aug 2012

Keywords

HIV and IL-21
IL-21 and B cells
IL-21 and immunity
IL-21 and T cells
Immunomodulation by IL-21

ASJC Scopus subject areas

Immunology
Endocrinology, Diabetes and Metabolism
Immunology and Allergy
Biochemistry, Genetics and Molecular Biology(all)

Access to Document

10.1016/j.cytogfr.2012.05.004

Fingerprint Dive into the research topics of 'The role of interleukin-21 in HIV infection'. Together they form a unique fingerprint.

Cite this

@article{08f22d904136402985fcf972af577516,

title = "The role of interleukin-21 in HIV infection",

abstract = "Interleukin (IL)-21 is one of a group of cytokines including IL-2, IL-4, IL-7, IL-9 and IL-15 whose receptor complexes share the common γ chain (γc). Secretion of IL-21 is restricted mainly to T follicular helper (TFH) CD4 T cell subset with contributions from Th17, natural killer (NK) T cells, but the effects of IL-21 are pleiotropic, owing to the broad cellular distribution of the IL-21 receptor. The role of IL-21 in sustaining and regulating T cell, B cell and NK cell responses during chronic viral infections has recently come into focus. This chapter reviews current knowledge about the biology of IL-21 in the context of HIV infection.",

keywords = "HIV and IL-21, IL-21 and B cells, IL-21 and immunity, IL-21 and T cells, Immunomodulation by IL-21",

author = "Suresh Pallikkuth and Anita Parmigiani and Savita Pahwa",

note = "Funding Information: This work was supported by NIH grant A1077501 to SP. ",

year = "2012",

month = aug,

doi = "10.1016/j.cytogfr.2012.05.004",

language = "English (US)",

volume = "23",

pages = "173--180",

journal = "Cytokine and Growth Factor Reviews",

issn = "1359-6101",

publisher = "Elsevier BV",

number = "4-5",

}

TY - JOUR

T1 - The role of interleukin-21 in HIV infection

AU - Pallikkuth, Suresh

AU - Parmigiani, Anita

AU - Pahwa, Savita

N1 - Funding Information: This work was supported by NIH grant A1077501 to SP.

PY - 2012/8

Y1 - 2012/8

N2 - Interleukin (IL)-21 is one of a group of cytokines including IL-2, IL-4, IL-7, IL-9 and IL-15 whose receptor complexes share the common γ chain (γc). Secretion of IL-21 is restricted mainly to T follicular helper (TFH) CD4 T cell subset with contributions from Th17, natural killer (NK) T cells, but the effects of IL-21 are pleiotropic, owing to the broad cellular distribution of the IL-21 receptor. The role of IL-21 in sustaining and regulating T cell, B cell and NK cell responses during chronic viral infections has recently come into focus. This chapter reviews current knowledge about the biology of IL-21 in the context of HIV infection.

AB - Interleukin (IL)-21 is one of a group of cytokines including IL-2, IL-4, IL-7, IL-9 and IL-15 whose receptor complexes share the common γ chain (γc). Secretion of IL-21 is restricted mainly to T follicular helper (TFH) CD4 T cell subset with contributions from Th17, natural killer (NK) T cells, but the effects of IL-21 are pleiotropic, owing to the broad cellular distribution of the IL-21 receptor. The role of IL-21 in sustaining and regulating T cell, B cell and NK cell responses during chronic viral infections has recently come into focus. This chapter reviews current knowledge about the biology of IL-21 in the context of HIV infection.

KW - HIV and IL-21

KW - IL-21 and B cells

KW - IL-21 and immunity

KW - IL-21 and T cells

KW - Immunomodulation by IL-21

UR - http://www.scopus.com/inward/record.url?scp=84864945744&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84864945744&partnerID=8YFLogxK

U2 - 10.1016/j.cytogfr.2012.05.004

DO - 10.1016/j.cytogfr.2012.05.004

M3 - Article

C2 - 22763176

AN - SCOPUS:84864945744

VL - 23

SP - 173

EP - 180

JO - Cytokine and Growth Factor Reviews

JF - Cytokine and Growth Factor Reviews

SN - 1359-6101

IS - 4-5

ER -