The role of interleukin-21 in HIV infection

Suresh Pallikkuth, Anita Parmigiani, Savita Pahwa

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Interleukin (IL)-21 is one of a group of cytokines including IL-2, IL-4, IL-7, IL-9 and IL-15 whose receptor complexes share the common γ chain (γc). Secretion of IL-21 is restricted mainly to T follicular helper (TFH) CD4 T cell subset with contributions from Th17, natural killer (NK) T cells, but the effects of IL-21 are pleiotropic, owing to the broad cellular distribution of the IL-21 receptor. The role of IL-21 in sustaining and regulating T cell, B cell and NK cell responses during chronic viral infections has recently come into focus. This chapter reviews current knowledge about the biology of IL-21 in the context of HIV infection.

Original languageEnglish (US)
Pages (from-to)173-180
Number of pages8
JournalCytokine and Growth Factor Reviews
Issue number4-5
StatePublished - Aug 2012


  • HIV and IL-21
  • IL-21 and B cells
  • IL-21 and immunity
  • IL-21 and T cells
  • Immunomodulation by IL-21

ASJC Scopus subject areas

  • Immunology
  • Endocrinology, Diabetes and Metabolism
  • Immunology and Allergy
  • Biochemistry, Genetics and Molecular Biology(all)


Dive into the research topics of 'The role of interleukin-21 in HIV infection'. Together they form a unique fingerprint.

Cite this