Abstract
Interleukin (IL)-21 is one of a group of cytokines including IL-2, IL-4, IL-7, IL-9 and IL-15 whose receptor complexes share the common γ chain (γc). Secretion of IL-21 is restricted mainly to T follicular helper (TFH) CD4 T cell subset with contributions from Th17, natural killer (NK) T cells, but the effects of IL-21 are pleiotropic, owing to the broad cellular distribution of the IL-21 receptor. The role of IL-21 in sustaining and regulating T cell, B cell and NK cell responses during chronic viral infections has recently come into focus. This chapter reviews current knowledge about the biology of IL-21 in the context of HIV infection.
| Original language | English |
|---|---|
| Pages (from-to) | 173-180 |
| Number of pages | 8 |
| Journal | Cytokine and Growth Factor Reviews |
| Volume | 23 |
| Issue number | 4-5 |
| DOIs | |
| State | Published - Aug 1 2012 |
Fingerprint
Keywords
- HIV and IL-21
- IL-21 and B cells
- IL-21 and immunity
- IL-21 and T cells
- Immunomodulation by IL-21
ASJC Scopus subject areas
- Immunology
- Endocrinology, Diabetes and Metabolism
- Immunology and Allergy
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
The role of interleukin-21 in HIV infection. / Pallikkuth, Suresh; Parmigiani, Anita; Pahwa, Savita G.
In: Cytokine and Growth Factor Reviews, Vol. 23, No. 4-5, 01.08.2012, p. 173-180.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The role of interleukin-21 in HIV infection
AU - Pallikkuth, Suresh
AU - Parmigiani, Anita
AU - Pahwa, Savita G
PY - 2012/8/1
Y1 - 2012/8/1
N2 - Interleukin (IL)-21 is one of a group of cytokines including IL-2, IL-4, IL-7, IL-9 and IL-15 whose receptor complexes share the common γ chain (γc). Secretion of IL-21 is restricted mainly to T follicular helper (TFH) CD4 T cell subset with contributions from Th17, natural killer (NK) T cells, but the effects of IL-21 are pleiotropic, owing to the broad cellular distribution of the IL-21 receptor. The role of IL-21 in sustaining and regulating T cell, B cell and NK cell responses during chronic viral infections has recently come into focus. This chapter reviews current knowledge about the biology of IL-21 in the context of HIV infection.
AB - Interleukin (IL)-21 is one of a group of cytokines including IL-2, IL-4, IL-7, IL-9 and IL-15 whose receptor complexes share the common γ chain (γc). Secretion of IL-21 is restricted mainly to T follicular helper (TFH) CD4 T cell subset with contributions from Th17, natural killer (NK) T cells, but the effects of IL-21 are pleiotropic, owing to the broad cellular distribution of the IL-21 receptor. The role of IL-21 in sustaining and regulating T cell, B cell and NK cell responses during chronic viral infections has recently come into focus. This chapter reviews current knowledge about the biology of IL-21 in the context of HIV infection.
KW - HIV and IL-21
KW - IL-21 and B cells
KW - IL-21 and immunity
KW - IL-21 and T cells
KW - Immunomodulation by IL-21
UR - http://www.scopus.com/inward/record.url?scp=84864945744&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84864945744&partnerID=8YFLogxK
U2 - 10.1016/j.cytogfr.2012.05.004
DO - 10.1016/j.cytogfr.2012.05.004
M3 - Article
C2 - 22763176
AN - SCOPUS:84864945744
VL - 23
SP - 173
EP - 180
JO - Cytokine and Growth Factor Reviews
JF - Cytokine and Growth Factor Reviews
SN - 1359-6101
IS - 4-5
ER -