The role of interleukin-21 in HIV infection

Suresh Pallikkuth; Anita Parmigiani; Savita Pahwa

doi:10.1016/j.cytogfr.2012.05.004

The role of interleukin-21 in HIV infection

Suresh Pallikkuth, Anita Parmigiani, Savita Pahwa

Microbiology & Immunology

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Interleukin (IL)-21 is one of a group of cytokines including IL-2, IL-4, IL-7, IL-9 and IL-15 whose receptor complexes share the common γ chain (γ_c). Secretion of IL-21 is restricted mainly to T follicular helper (TFH) CD4 T cell subset with contributions from Th17, natural killer (NK) T cells, but the effects of IL-21 are pleiotropic, owing to the broad cellular distribution of the IL-21 receptor. The role of IL-21 in sustaining and regulating T cell, B cell and NK cell responses during chronic viral infections has recently come into focus. This chapter reviews current knowledge about the biology of IL-21 in the context of HIV infection.

Original language	English (US)
Pages (from-to)	173-180
Number of pages	8
Journal	Cytokine and Growth Factor Reviews
Volume	23
Issue number	4-5
DOIs	https://doi.org/10.1016/j.cytogfr.2012.05.004
State	Published - Aug 2012

Keywords

HIV and IL-21
IL-21 and B cells
IL-21 and immunity
IL-21 and T cells
Immunomodulation by IL-21

ASJC Scopus subject areas

Immunology
Endocrinology, Diabetes and Metabolism
Immunology and Allergy
Biochemistry, Genetics and Molecular Biology(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.cytogfr.2012.05.004

Cite this

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title = "The role of interleukin-21 in HIV infection",

abstract = "Interleukin (IL)-21 is one of a group of cytokines including IL-2, IL-4, IL-7, IL-9 and IL-15 whose receptor complexes share the common γ chain (γc). Secretion of IL-21 is restricted mainly to T follicular helper (TFH) CD4 T cell subset with contributions from Th17, natural killer (NK) T cells, but the effects of IL-21 are pleiotropic, owing to the broad cellular distribution of the IL-21 receptor. The role of IL-21 in sustaining and regulating T cell, B cell and NK cell responses during chronic viral infections has recently come into focus. This chapter reviews current knowledge about the biology of IL-21 in the context of HIV infection.",

keywords = "HIV and IL-21, IL-21 and B cells, IL-21 and immunity, IL-21 and T cells, Immunomodulation by IL-21",

author = "Suresh Pallikkuth and Anita Parmigiani and Savita Pahwa",

note = "Funding Information: This work was supported by NIH grant A1077501 to SP. ",

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doi = "10.1016/j.cytogfr.2012.05.004",

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AU - Pallikkuth, Suresh

AU - Parmigiani, Anita

AU - Pahwa, Savita

N1 - Funding Information: This work was supported by NIH grant A1077501 to SP.

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N2 - Interleukin (IL)-21 is one of a group of cytokines including IL-2, IL-4, IL-7, IL-9 and IL-15 whose receptor complexes share the common γ chain (γc). Secretion of IL-21 is restricted mainly to T follicular helper (TFH) CD4 T cell subset with contributions from Th17, natural killer (NK) T cells, but the effects of IL-21 are pleiotropic, owing to the broad cellular distribution of the IL-21 receptor. The role of IL-21 in sustaining and regulating T cell, B cell and NK cell responses during chronic viral infections has recently come into focus. This chapter reviews current knowledge about the biology of IL-21 in the context of HIV infection.

AB - Interleukin (IL)-21 is one of a group of cytokines including IL-2, IL-4, IL-7, IL-9 and IL-15 whose receptor complexes share the common γ chain (γc). Secretion of IL-21 is restricted mainly to T follicular helper (TFH) CD4 T cell subset with contributions from Th17, natural killer (NK) T cells, but the effects of IL-21 are pleiotropic, owing to the broad cellular distribution of the IL-21 receptor. The role of IL-21 in sustaining and regulating T cell, B cell and NK cell responses during chronic viral infections has recently come into focus. This chapter reviews current knowledge about the biology of IL-21 in the context of HIV infection.

KW - HIV and IL-21

KW - IL-21 and B cells

KW - IL-21 and immunity

KW - IL-21 and T cells

KW - Immunomodulation by IL-21

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The role of interleukin-21 in HIV infection

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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