The role of inflammatory processes in the pathophysiology and treatment of brain and spinal cord trauma

W. Dalton Dietrich, K. Chatzipanteli, E. Vitarbo, K. Wada, K. Kinoshita

Research output: Contribution to journalArticle

70 Citations (Scopus)

Abstract

Traumatic injury to the brain and spinal cord results in an early inflammatory response that is initiated by the release of proinflammatory cytokines followed by the infiltration and accumulation of polymorphonuclear leukocytes (PMNLs). The role of the inflammatory cascade on traumatic outcome remains controversial. Pleiotropic cytokines appear to function both protectively and destructively. The induction of cytokines can lead to the expression of the inducible form of nitric oxide synthase (iNOS), which in turn provokes the release of excessive amounts of nitric oxide (NO) that may participate in the pathogenesis of tissue injury. Hypothermia has been reported by various groups to be neuroprotective in brain and spinal cord trauma. We studied the effect of therapeutic hypothermia on cerebral IL-lp concentrations, PMNL accumulation and iNOS activity after traumatic brain injury (TBI) and spinal cord injury (SCI). Based on current data therapeutic hypothermia may protect in models of traumatic injury by modulating deleterious inflammatory processes.

Original languageEnglish
Pages (from-to)69-74
Number of pages6
JournalActa Neurochirurgica, Supplementum
Issue number89
StatePublished - Dec 1 2004

Fingerprint

hypothermia
Hypothermia
spinal cord
Nitric oxide
nitric oxide
Spinal Cord Injuries
brain
Induced Hypothermia
Brain
leukocytes
Nitric Oxide Synthase Type II
Cytokines
Nitric Oxide Synthase
Neutrophils
spinal cord injuries
brain damage
pathogenesis
Wounds and Injuries
infiltration
Infiltration

Keywords

  • Hypothermia
  • Interleukin-1 beta (il-1β)
  • Spinal cord injury (SCI)
  • Traumatic brain injury (TBI)

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery
  • Medicine(all)

Cite this

The role of inflammatory processes in the pathophysiology and treatment of brain and spinal cord trauma. / Dalton Dietrich, W.; Chatzipanteli, K.; Vitarbo, E.; Wada, K.; Kinoshita, K.

In: Acta Neurochirurgica, Supplementum, No. 89, 01.12.2004, p. 69-74.

Research output: Contribution to journalArticle

@article{f6ada5cb1d3e4ef782e262cef3a786c6,
title = "The role of inflammatory processes in the pathophysiology and treatment of brain and spinal cord trauma",
abstract = "Traumatic injury to the brain and spinal cord results in an early inflammatory response that is initiated by the release of proinflammatory cytokines followed by the infiltration and accumulation of polymorphonuclear leukocytes (PMNLs). The role of the inflammatory cascade on traumatic outcome remains controversial. Pleiotropic cytokines appear to function both protectively and destructively. The induction of cytokines can lead to the expression of the inducible form of nitric oxide synthase (iNOS), which in turn provokes the release of excessive amounts of nitric oxide (NO) that may participate in the pathogenesis of tissue injury. Hypothermia has been reported by various groups to be neuroprotective in brain and spinal cord trauma. We studied the effect of therapeutic hypothermia on cerebral IL-lp concentrations, PMNL accumulation and iNOS activity after traumatic brain injury (TBI) and spinal cord injury (SCI). Based on current data therapeutic hypothermia may protect in models of traumatic injury by modulating deleterious inflammatory processes.",
keywords = "Hypothermia, Interleukin-1 beta (il-1β), Spinal cord injury (SCI), Traumatic brain injury (TBI)",
author = "{Dalton Dietrich}, W. and K. Chatzipanteli and E. Vitarbo and K. Wada and K. Kinoshita",
year = "2004",
month = "12",
day = "1",
language = "English",
pages = "69--74",
journal = "Scientific Computing and Instrumentation",
issn = "1078-8956",
publisher = "Springer Wien",
number = "89",

}

TY - JOUR

T1 - The role of inflammatory processes in the pathophysiology and treatment of brain and spinal cord trauma

AU - Dalton Dietrich, W.

AU - Chatzipanteli, K.

AU - Vitarbo, E.

AU - Wada, K.

AU - Kinoshita, K.

PY - 2004/12/1

Y1 - 2004/12/1

N2 - Traumatic injury to the brain and spinal cord results in an early inflammatory response that is initiated by the release of proinflammatory cytokines followed by the infiltration and accumulation of polymorphonuclear leukocytes (PMNLs). The role of the inflammatory cascade on traumatic outcome remains controversial. Pleiotropic cytokines appear to function both protectively and destructively. The induction of cytokines can lead to the expression of the inducible form of nitric oxide synthase (iNOS), which in turn provokes the release of excessive amounts of nitric oxide (NO) that may participate in the pathogenesis of tissue injury. Hypothermia has been reported by various groups to be neuroprotective in brain and spinal cord trauma. We studied the effect of therapeutic hypothermia on cerebral IL-lp concentrations, PMNL accumulation and iNOS activity after traumatic brain injury (TBI) and spinal cord injury (SCI). Based on current data therapeutic hypothermia may protect in models of traumatic injury by modulating deleterious inflammatory processes.

AB - Traumatic injury to the brain and spinal cord results in an early inflammatory response that is initiated by the release of proinflammatory cytokines followed by the infiltration and accumulation of polymorphonuclear leukocytes (PMNLs). The role of the inflammatory cascade on traumatic outcome remains controversial. Pleiotropic cytokines appear to function both protectively and destructively. The induction of cytokines can lead to the expression of the inducible form of nitric oxide synthase (iNOS), which in turn provokes the release of excessive amounts of nitric oxide (NO) that may participate in the pathogenesis of tissue injury. Hypothermia has been reported by various groups to be neuroprotective in brain and spinal cord trauma. We studied the effect of therapeutic hypothermia on cerebral IL-lp concentrations, PMNL accumulation and iNOS activity after traumatic brain injury (TBI) and spinal cord injury (SCI). Based on current data therapeutic hypothermia may protect in models of traumatic injury by modulating deleterious inflammatory processes.

KW - Hypothermia

KW - Interleukin-1 beta (il-1β)

KW - Spinal cord injury (SCI)

KW - Traumatic brain injury (TBI)

UR - http://www.scopus.com/inward/record.url?scp=4544248921&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=4544248921&partnerID=8YFLogxK

M3 - Article

C2 - 15335103

AN - SCOPUS:4544248921

SP - 69

EP - 74

JO - Scientific Computing and Instrumentation

JF - Scientific Computing and Instrumentation

SN - 1078-8956

IS - 89

ER -