Abstract
In patients with localised prostate cancer and a life expectancy of at least 10 years, radical prostatectomy is increasingly being performed. Pre-operative clinical staging of prostate cancer is, however, inaccurate with around 10-20% of clinical T1, 10-30% of clinical T2(a), and 30-60% of clinical T2(b) cases having tumour at the surgical margin. There is no documented best treatment for patients with a positive surgical margin. Options include close observation, adjuvant radiation therapy or androgen deprivation. The role of induction androgen deprivation has, therefore, evolved in an attempt to improve upon the cure rate for radical prostatectomy, and in this review results from clinical trials are discussed. In the largest United States randomised trial in patients with stage T2(b) prostate cancer, pre-operative androgen deprivation resulted in a significantly lower rate of positive surgical margins, normalisation of prostate-specific antigen and a decrease in the size of the prostate. Sufficient follow-up is required from all of the completed prospective randomised trials before pre-operative androgen deprivation can be justified in all T2(b) patients.
| Original language | English |
|---|---|
| Pages (from-to) | 114-118 |
| Number of pages | 5 |
| Journal | European Urology |
| Volume | 29 |
| Issue number | SUPPL. 2 |
| State | Published - May 1 1996 |
| Externally published | Yes |
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Keywords
- Induction androgen deprivation
- Neoadjuvant therapy
- Prostate cancer
- Radical prostatectomy
ASJC Scopus subject areas
- Urology
Cite this
The role of induction androgen deprivation prior to radical prostatectomy. / Soloway, M. S.; Watson, R.
In: European Urology, Vol. 29, No. SUPPL. 2, 01.05.1996, p. 114-118.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The role of induction androgen deprivation prior to radical prostatectomy
AU - Soloway, M. S.
AU - Watson, R.
PY - 1996/5/1
Y1 - 1996/5/1
N2 - In patients with localised prostate cancer and a life expectancy of at least 10 years, radical prostatectomy is increasingly being performed. Pre-operative clinical staging of prostate cancer is, however, inaccurate with around 10-20% of clinical T1, 10-30% of clinical T2(a), and 30-60% of clinical T2(b) cases having tumour at the surgical margin. There is no documented best treatment for patients with a positive surgical margin. Options include close observation, adjuvant radiation therapy or androgen deprivation. The role of induction androgen deprivation has, therefore, evolved in an attempt to improve upon the cure rate for radical prostatectomy, and in this review results from clinical trials are discussed. In the largest United States randomised trial in patients with stage T2(b) prostate cancer, pre-operative androgen deprivation resulted in a significantly lower rate of positive surgical margins, normalisation of prostate-specific antigen and a decrease in the size of the prostate. Sufficient follow-up is required from all of the completed prospective randomised trials before pre-operative androgen deprivation can be justified in all T2(b) patients.
AB - In patients with localised prostate cancer and a life expectancy of at least 10 years, radical prostatectomy is increasingly being performed. Pre-operative clinical staging of prostate cancer is, however, inaccurate with around 10-20% of clinical T1, 10-30% of clinical T2(a), and 30-60% of clinical T2(b) cases having tumour at the surgical margin. There is no documented best treatment for patients with a positive surgical margin. Options include close observation, adjuvant radiation therapy or androgen deprivation. The role of induction androgen deprivation has, therefore, evolved in an attempt to improve upon the cure rate for radical prostatectomy, and in this review results from clinical trials are discussed. In the largest United States randomised trial in patients with stage T2(b) prostate cancer, pre-operative androgen deprivation resulted in a significantly lower rate of positive surgical margins, normalisation of prostate-specific antigen and a decrease in the size of the prostate. Sufficient follow-up is required from all of the completed prospective randomised trials before pre-operative androgen deprivation can be justified in all T2(b) patients.
KW - Induction androgen deprivation
KW - Neoadjuvant therapy
KW - Prostate cancer
KW - Radical prostatectomy
UR - http://www.scopus.com/inward/record.url?scp=0029921923&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029921923&partnerID=8YFLogxK
M3 - Article
C2 - 8717473
AN - SCOPUS:0029921923
VL - 29
SP - 114
EP - 118
JO - European Urology
JF - European Urology
SN - 0302-2838
IS - SUPPL. 2
ER -