The role of histone acetyltransferases in normal and malignant hematopoiesis

Xiao Jian Sun, Na Man, Yurong Tan, Stephen D. Nimer, Lan Wang

Research output: Contribution to journalReview article

44 Scopus citations

Abstract

Histone, and non-histone, protein acetylation plays an important role in a variety of cellular events, including the normal and abnormal development of blood cells, by changing the epigenetic status of chromatin and regulating non-histone protein function. Histone acetyltransferases (HATs), which are the enzymes responsible for histone and non-histone protein acetylation, contain p300/CBP, MYST, and GNAT family members. HATs are not only protein modifiers and epigenetic factors but also critical regulators of cell development and carcinogenesis. Here, we will review the function of HATs such as p300/CBP, Tip60, MOZ/MORF, and GCN5/PCAF in normal hematopoiesis and the pathogenesis of hematological malignancies. The inhibitors that have been developed to target HATs will also be reviewed here. Understanding the roles of HATs in normal/malignant hematopoiesis will provide the potential therapeutic targets for the hematological malignancies.

Original languageEnglish (US)
Article number108
JournalFrontiers in Oncology
Volume5
Issue numberMAY
DOIs
StatePublished - 2015

Keywords

  • Hematological malignancies
  • Hematopoiesis
  • Hematopoietic stem cells
  • Histone acetyltransferases
  • Transcriptional regulation

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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