The role of glutamate antagonists for the treatment of CNS injury

Ross Bullock, H. Fujisawa

Research output: Contribution to journalArticle

125 Citations (Scopus)

Abstract

Ischemic damage, chiefly of the focal type, and axonal disruption (diffuse axonal injury) are the major factors causing brain damage after human head injury. About one third of this damage may be delayed hours or days after the injury. Evidence from four animal models, each relevant to different aspects of human head injury, has shown that excitatory amino acid-induced changes are responsible for a proportion of the posttraumatic sequelae and that these effects can be blocked by EAA antagonists. This evidence is reviewed, and the implications for the conduct of human trials with EAA antagonists are discussed.

Original languageEnglish
JournalJournal of Neurotrauma
Volume9
Issue numberSUPPL. 2
StatePublished - Jan 1 1992
Externally publishedYes

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Excitatory Amino Acid Antagonists
Craniocerebral Trauma
Wounds and Injuries
Diffuse Axonal Injury
Excitatory Amino Acids
Animal Models
Brain

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

The role of glutamate antagonists for the treatment of CNS injury. / Bullock, Ross; Fujisawa, H.

In: Journal of Neurotrauma, Vol. 9, No. SUPPL. 2, 01.01.1992.

Research output: Contribution to journalArticle

Bullock, R & Fujisawa, H 1992, 'The role of glutamate antagonists for the treatment of CNS injury', Journal of Neurotrauma, vol. 9, no. SUPPL. 2.
Bullock, Ross ; Fujisawa, H. / The role of glutamate antagonists for the treatment of CNS injury. In: Journal of Neurotrauma. 1992 ; Vol. 9, No. SUPPL. 2.
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