The Role of Excitatory Amino Acids in Severe Brain Trauma: Opportunities for Therapy: A Review

Alois Zauner, Ross Bullock

Research output: Contribution to journalArticle

64 Scopus citations

Abstract

Severe brain trauma remains poorly understood, because of its pathophysiological complexity, and this has so far thwarted our attempts to improve outcome by means of drug therapy, although better understanding of the role of ischemic events has led to improved mortality rates, in some centers. With regard to excitatory amino acid antagonists, new mechanistic insights from both animal models, and human monitoring has enabled better trial design, which may allow the tremendous laboratory neuroprotective potency of this group of compounds to be translated to clinical benefit.

Original languageEnglish (US)
Pages (from-to)547-554
Number of pages8
JournalJournal of neurotrauma
Volume12
Issue number4
DOIs
StatePublished - Aug 1995

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Keywords

  • brain trauma
  • excitatory amino acids
  • glutamate
  • ion channels

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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