The role of EF-hand Ca2+/Mg2+-binding tescalcin protein in cell proliferation and differentiation

K. G. Kolobynina, V. V. Solovyeva, Vladlen Z Slepak, A. A. Rizvanov

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

EF-hand Ca2+/Mg2+-binding proteins are involved in many important processes in the body. Identification and analysis of the EF-hand motifs in the genome led to the discovery of novel Ca2+-binding proteins, which are potentially useful for biomedical applications. One of such molecules is tescalcin - 24 kDa protein with one EF-hand motif. Tescalcin plays an important role in differentiation of hematopoietic cells by regulating the expression of Ets family transcription factors via PMA-induced ERK-pathway. At the molecular level, it was shown to interact with subunit 4 of signalosome COP9 and Na+/H+-exchanger. Recently a potential use of tescalcin for cancer diagnostics was demonstrated.

Original languageEnglish (US)
Pages (from-to)28-34
Number of pages7
JournalGenes and Cells
Volume10
Issue number1
StatePublished - 2015

Fingerprint

EF Hand Motifs
Cell proliferation
Cell Differentiation
Carrier Proteins
Cell Proliferation
Transcription factors
Proto-Oncogene Proteins c-ets
Sodium-Hydrogen Antiporter
MAP Kinase Signaling System
Genes
Cells
Proteins
Molecules
Genome
Neoplasms

Keywords

  • Cell differentiation
  • COP9
  • CSN complex
  • EF-hand calcium-binding proteins
  • Oncological diseases
  • Tescalcin

ASJC Scopus subject areas

  • Surgery
  • Biotechnology
  • Biomedical Engineering
  • Molecular Biology
  • Cell Biology
  • Transplantation

Cite this

The role of EF-hand Ca2+/Mg2+-binding tescalcin protein in cell proliferation and differentiation. / Kolobynina, K. G.; Solovyeva, V. V.; Slepak, Vladlen Z; Rizvanov, A. A.

In: Genes and Cells, Vol. 10, No. 1, 2015, p. 28-34.

Research output: Contribution to journalReview article

Kolobynina, KG, Solovyeva, VV, Slepak, VZ & Rizvanov, AA 2015, 'The role of EF-hand Ca2+/Mg2+-binding tescalcin protein in cell proliferation and differentiation', Genes and Cells, vol. 10, no. 1, pp. 28-34.
Kolobynina, K. G. ; Solovyeva, V. V. ; Slepak, Vladlen Z ; Rizvanov, A. A. / The role of EF-hand Ca2+/Mg2+-binding tescalcin protein in cell proliferation and differentiation. In: Genes and Cells. 2015 ; Vol. 10, No. 1. pp. 28-34.
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