The role of EF-hand Ca2+/Mg2+-binding tescalcin protein in cell proliferation and differentiation

K. G. Kolobynina, V. V. Solovyeva, Vladlen Z Slepak, A. A. Rizvanov

Research output: Contribution to journalReview article

1 Scopus citations

Abstract

EF-hand Ca2+/Mg2+-binding proteins are involved in many important processes in the body. Identification and analysis of the EF-hand motifs in the genome led to the discovery of novel Ca2+-binding proteins, which are potentially useful for biomedical applications. One of such molecules is tescalcin - 24 kDa protein with one EF-hand motif. Tescalcin plays an important role in differentiation of hematopoietic cells by regulating the expression of Ets family transcription factors via PMA-induced ERK-pathway. At the molecular level, it was shown to interact with subunit 4 of signalosome COP9 and Na+/H+-exchanger. Recently a potential use of tescalcin for cancer diagnostics was demonstrated.

Original languageEnglish (US)
Pages (from-to)28-34
Number of pages7
JournalGenes and Cells
Volume10
Issue number1
StatePublished - 2015

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Keywords

  • Cell differentiation
  • COP9
  • CSN complex
  • EF-hand calcium-binding proteins
  • Oncological diseases
  • Tescalcin

ASJC Scopus subject areas

  • Surgery
  • Biotechnology
  • Biomedical Engineering
  • Molecular Biology
  • Cell Biology
  • Transplantation

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