The Role of Dopamine in the Pathophysiology and Treatment of Major Depressive Disorder

Boadie W. Dunlop, Charles Nemeroff

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

Many of the studies exploring dopamine (DA) function in depression have produced inconsistent findings. Contributors to this inconsistency include the diagnostic heterogeneity of major depressive disorder (MDD); failure to control for age, bipolar disorder, and comorbid diagnoses; and variation in patient medication treatment status at the time of the study. Despite this variability, there is now a convergence of data from animal models, genetics, neuroimaging, and human clinical trials that strengthens the case for DA dysfunction in the pathophysiology of major depression, at least in a significant subgroup of patients. This chapter comprehensively reviews the current evidence, with subsequent recommendations for future studies of dopaminergic signaling in depression and its treatment.

Original languageEnglish
Title of host publicationDopamine Handbook
PublisherOxford University Press
ISBN (Print)9780199865543, 9780195373035
DOIs
StatePublished - Feb 1 2010
Externally publishedYes

Fingerprint

Major Depressive Disorder
Dopamine
Depression
Time and Motion Studies
Medical Genetics
Bipolar Disorder
Neuroimaging
Therapeutics
Animal Models
Clinical Trials

Keywords

  • Depression
  • Dopamine dysfunction
  • Major depressive disorder
  • Pathophysiology

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

The Role of Dopamine in the Pathophysiology and Treatment of Major Depressive Disorder. / Dunlop, Boadie W.; Nemeroff, Charles.

Dopamine Handbook. Oxford University Press, 2010.

Research output: Chapter in Book/Report/Conference proceedingChapter

Dunlop, Boadie W. ; Nemeroff, Charles. / The Role of Dopamine in the Pathophysiology and Treatment of Major Depressive Disorder. Dopamine Handbook. Oxford University Press, 2010.
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