The Role of Dopamine in the Pathophysiology and Treatment of Major Depressive Disorder

Boadie W. Dunlop, Charles B. Nemeroff

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


Many of the studies exploring dopamine (DA) function in depression have produced inconsistent findings. Contributors to this inconsistency include the diagnostic heterogeneity of major depressive disorder (MDD); failure to control for age, bipolar disorder, and comorbid diagnoses; and variation in patient medication treatment status at the time of the study. Despite this variability, there is now a convergence of data from animal models, genetics, neuroimaging, and human clinical trials that strengthens the case for DA dysfunction in the pathophysiology of major depression, at least in a significant subgroup of patients. This chapter comprehensively reviews the current evidence, with subsequent recommendations for future studies of dopaminergic signaling in depression and its treatment.

Original languageEnglish (US)
Title of host publicationDopamine Handbook
PublisherOxford University Press
ISBN (Electronic)9780199865543
ISBN (Print)9780195373035
StatePublished - Feb 1 2010
Externally publishedYes


  • Depression
  • Dopamine dysfunction
  • Major depressive disorder
  • Pathophysiology

ASJC Scopus subject areas

  • Neuroscience(all)


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