The role of donor bone marrow infusions in withdrawal of immunosuppression in adult liver allotransplantation

Panagiotis Tryphonopoulos, Andreas G. Tzakis, Debbie Weppler, Rolando Garcia-Morales, Tomoaki Kato, Juan R. Madariaga, David M. Levi, Seigo Nishida, Jang Moon, Gennaro Selvaggi, Arie Regev, Caio Nery, Pablo A Bejarano, Amr Khaled, Gary Kleiner, Violet Esquenazi, Joshua Miller, Philip Ruiz, Camillo Ricordi

Research output: Contribution to journalArticle

87 Scopus citations

Abstract

We investigated the role of donor bone marrow cell (DBMC) infusions in immunosuppression withdrawal in adult liver transplantation. Patients enrolled were at least 3 years post-transplantation, with stable graft function. Forty-five (study group: G1) received DBMC, and 59 (control group: G2) did not. Immunosuppression was reduced by one third upon enrollment, by another third the second year of the study and was completely withdrawn the third year. Patient and graft survival were similar between the two groups. Although rejection episodes were significantly less in G1 the first 2 years of the study (35% vs. 57%, p = 0.016), there was no significant difference overall (74% vs. 81%, p = 0.14). Until February 2004, 20 patients, 10 in each group, were immunosuppression free for 1-3 years. Approximately 20% of long-term survivors of liver transplantation can successfully discontinue their immunosuppression. DBMC infusions, do not increase this likelihood.

Original languageEnglish (US)
Pages (from-to)608-613
Number of pages6
JournalAmerican Journal of Transplantation
Volume5
Issue number3
DOIs
StatePublished - Mar 1 2005

Keywords

  • Donor bone narrow infusion
  • Immunosuppression withdrawal
  • Liver transplantation
  • Tolerance

ASJC Scopus subject areas

  • Immunology

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    Tryphonopoulos, P., Tzakis, A. G., Weppler, D., Garcia-Morales, R., Kato, T., Madariaga, J. R., Levi, D. M., Nishida, S., Moon, J., Selvaggi, G., Regev, A., Nery, C., Bejarano, P. A., Khaled, A., Kleiner, G., Esquenazi, V., Miller, J., Ruiz, P., & Ricordi, C. (2005). The role of donor bone marrow infusions in withdrawal of immunosuppression in adult liver allotransplantation. American Journal of Transplantation, 5(3), 608-613. https://doi.org/10.1111/j.1600-6143.2004.00743.x