The role of deoxyribonucleic acid methylation in development, diagnosis, and prognosis of bladder cancer

Mark L Gonzalgo, Ram Datar, Mark P. Schoenberg, Richard J Cote

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Alterations in global levels and regional patterns of deoxyribonucleic acid methylation are among the earliest and most common events known to occur in human cancer. The mutational and epigenetic effects of this covalent deoxyribonucleic acid modification to the development of bladder cancer are well recognized. The contribution of aberrant methylation to mutational hot spots located within genes, transcriptional silencing, and chromosomal instability is reviewed in the context of its relevance to bladder carcinogenesis. Understanding how such processes evolve during the progression of bladder cancer is essential for using these molecular changes in the clinical setting. The recent development of sensitive and specific techniques for quantifying methylation changes in urine specimens and bodily fluids underscores the potential use of this molecular marker for early detection and surveillance of bladder cancer. Further refinement of these molecular biological techniques holds much promise for the use of methylation markers for bladder cancer diagnosis, risk stratification, and disease prognostication.

Original languageEnglish
Pages (from-to)228-235
Number of pages8
JournalUrologic Oncology: Seminars and Original Investigations
Volume25
Issue number3
DOIs
StatePublished - May 1 2007
Externally publishedYes

Fingerprint

Urinary Bladder Neoplasms
Methylation
DNA
Chromosomal Instability
Gene Silencing
Epigenomics
Carcinogenesis
Urinary Bladder
Urine
Neoplasms

Keywords

  • Bladder cancer
  • Diagnosis
  • DNA methylation
  • Prognosis

ASJC Scopus subject areas

  • Oncology
  • Urology

Cite this

The role of deoxyribonucleic acid methylation in development, diagnosis, and prognosis of bladder cancer. / Gonzalgo, Mark L; Datar, Ram; Schoenberg, Mark P.; Cote, Richard J.

In: Urologic Oncology: Seminars and Original Investigations, Vol. 25, No. 3, 01.05.2007, p. 228-235.

Research output: Contribution to journalArticle

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