The role of deimination in ATP5b mRNA transport in a transgenic mouse model of multiple sclerosis

Di Ding, Mabel Enriquez-Algeciras, Kunjan R. Dave, Miguel Perez-Pinzon, Sanjoy K. Bhattacharya

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Deimination refers to conversion of protein-bound arginine into citrulline. An mRNA carrier, RNA binding export factor (REF), present on mitochondria undergoes loss of deimination with impaired ATP5b mRNA transport in ND4 mice (model of multiple sclerosis) compared with the controls. We present evidence of (1) reduced ATP5b mRNA binding strength of non-deiminated REF compared with deiminated REF, (2) impaired ATP5b mRNA transport in ND4 mice and (3) reduced mitochondrial ATP synthase activity on inhibition of deimination in PC12 cells. Impaired deimination of REF and defect in mitochondrial mRNA transport are critical factors in mitochondrial dysfunction in ND4 mice.

Original languageEnglish (US)
Pages (from-to)230-236
Number of pages7
JournalEMBO Reports
Volume13
Issue number3
DOIs
StatePublished - Mar 2012

Keywords

  • ATP synthase
  • deimination
  • mitochondria
  • multiple sclerosis
  • RNA binding export factor

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Biochemistry

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