The role of cytotoxic and regulatory T cells in relapsed/refractory hodgkin lymphoma

Aashiyana F. Koreishi, Adam J. Saenz, Dan O. Persky, Hayan Cui, Allison Moskowitz, Craig Moskowitz, Julie Teruya-Feldstein

Research output: Contribution to journalArticle

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Abstract

Recent data suggests the presence of cytotoxic (TIA-1 and granzyme B+) and regulatory T-cells (FOXP3+) in classical Hodgkin lymphoma (cHL) tissues has been shown to correlate with poor overall survival in mainly diagnostic biopsies. By tissue microarray analyses, we extend this observation to a cohort of relapsed/refractory cHL tissue biopsies and analyze immunohistochemical expression of FOXP3, TIA-1, and granzyme B in the inflammatory background and the tumor microenvironment. High expression of TIA-1 (>50%) correlated with poor overall survival (P<0.0001), low expression of FOXP3 (<25%) correlated with poor overall survival (P<0.01), and combined high TIA-1 (>50%) and low FOXP3 (<25%) correlated with poor overall survival (P<0.0001). Expression of cytotoxic and regulatory T-cells shows prognostic significance in the relapsed/refractory clinical setting of cHL.

Original languageEnglish (US)
Pages (from-to)206-211
Number of pages6
JournalApplied Immunohistochemistry and Molecular Morphology
Volume18
Issue number3
DOIs
StatePublished - May 1 2010
Externally publishedYes

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Regulatory T-Lymphocytes
Hodgkin Disease
Granzymes
Tissue Array Analysis
Biopsy
Tumor Microenvironment

Keywords

  • Biomarkers
  • Hodgkin lymphoma
  • Immunohistochemistry
  • Relapsed/refractory

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology
  • Histology

Cite this

The role of cytotoxic and regulatory T cells in relapsed/refractory hodgkin lymphoma. / Koreishi, Aashiyana F.; Saenz, Adam J.; Persky, Dan O.; Cui, Hayan; Moskowitz, Allison; Moskowitz, Craig; Teruya-Feldstein, Julie.

In: Applied Immunohistochemistry and Molecular Morphology, Vol. 18, No. 3, 01.05.2010, p. 206-211.

Research output: Contribution to journalArticle

Koreishi, Aashiyana F. ; Saenz, Adam J. ; Persky, Dan O. ; Cui, Hayan ; Moskowitz, Allison ; Moskowitz, Craig ; Teruya-Feldstein, Julie. / The role of cytotoxic and regulatory T cells in relapsed/refractory hodgkin lymphoma. In: Applied Immunohistochemistry and Molecular Morphology. 2010 ; Vol. 18, No. 3. pp. 206-211.
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