The role of cytotoxic and regulatory T cells in relapsed/refractory hodgkin lymphoma

Aashiyana F. Koreishi, Adam J. Saenz, Dan O. Persky, Hayan Cui, Allison Moskowitz, Craig H. Moskowitz, Julie Teruya-Feldstein

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

Recent data suggests the presence of cytotoxic (TIA-1 and granzyme B+) and regulatory T-cells (FOXP3+) in classical Hodgkin lymphoma (cHL) tissues has been shown to correlate with poor overall survival in mainly diagnostic biopsies. By tissue microarray analyses, we extend this observation to a cohort of relapsed/refractory cHL tissue biopsies and analyze immunohistochemical expression of FOXP3, TIA-1, and granzyme B in the inflammatory background and the tumor microenvironment. High expression of TIA-1 (>50%) correlated with poor overall survival (P<0.0001), low expression of FOXP3 (<25%) correlated with poor overall survival (P<0.01), and combined high TIA-1 (>50%) and low FOXP3 (<25%) correlated with poor overall survival (P<0.0001). Expression of cytotoxic and regulatory T-cells shows prognostic significance in the relapsed/refractory clinical setting of cHL.

Original languageEnglish (US)
Pages (from-to)206-211
Number of pages6
JournalApplied Immunohistochemistry and Molecular Morphology
Volume18
Issue number3
DOIs
StatePublished - May 2010
Externally publishedYes

Keywords

  • Biomarkers
  • Hodgkin lymphoma
  • Immunohistochemistry
  • Relapsed/refractory

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology
  • Medical Laboratory Technology

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