The role of crystals in osteoarthritis

L. M. Ryan, Herman S Cheung

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Calcium-containing crystals, such as calcium pyrophosphate dihydrate and basic calcium phosphate, have profound in vitro biologic effects. They promote synovial hyperplasia and synthesis of metalloproteases able to degrade cartilage matrix. Clinical observations support the thesis that these in vitro effects also occur in vivo. Prospects for successful interventions in the crystal deposition diseases depend upon better understanding of the mechanisms of crystal formation and activation pathways that lead to their biologic effects.

Original languageEnglish
Pages (from-to)257-267
Number of pages11
JournalRheumatic Disease Clinics of North America
Volume25
Issue number2
DOIs
StatePublished - Jun 21 1999
Externally publishedYes

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Osteoarthritis
Calcium Pyrophosphate
Metalloproteases
Cartilage
Hyperplasia
Calcium
In Vitro Techniques
dihydrate calcium phosphate

ASJC Scopus subject areas

  • Rheumatology

Cite this

The role of crystals in osteoarthritis. / Ryan, L. M.; Cheung, Herman S.

In: Rheumatic Disease Clinics of North America, Vol. 25, No. 2, 21.06.1999, p. 257-267.

Research output: Contribution to journalArticle

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