The role of Corticotropin-Releasing Hormone in the Pathophysiology of Depression: Therapeutic Implications

R. Brett Lloyd, Charles Nemeroff

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Stress responses have been posited to be a key component of mental health and disease by playing essential roles both in normal adaptive processes and maladaptive physiological responses that in part underlie the pathogenesis of certain subtypes of mood and anxiety disorders. Early research focused on delineating the function of the hypothalamicpituitary-adrenal (HPA) axis and subsequently examined its role in mediating the mammalian stress responses and its hyperactivity in depression. Much evidence now supports an important function of the biological mediators of this system in relation to not only depression, but also anxiety, substance abuse, and psychotic disorders, and implicates several components of this system as areas of intervention for novel pharmacotherapy. Perhaps the best studied central nervous system (CNS) component of this system is corticotropin-releasing factor (CRF), and considerable research has focused on its role in the HPA axis, as well in extrahypothalamic brain regions.

Original languageEnglish
Pages (from-to)609-617
Number of pages9
JournalCurrent Topics in Medicinal Chemistry
Volume11
Issue number6
StatePublished - Mar 28 2011

Fingerprint

Corticotropin-Releasing Hormone
Depression
Physiological Phenomena
Anxiety Disorders
Mood Disorders
Research
Psychotic Disorders
Substance-Related Disorders
Mental Health
Anxiety
Central Nervous System
Drug Therapy
Brain
Therapeutics

Keywords

  • Corticotropin-releasing factor
  • depression
  • early life stress
  • hypothalamic-pituitary-adrenal axis

ASJC Scopus subject areas

  • Drug Discovery

Cite this

The role of Corticotropin-Releasing Hormone in the Pathophysiology of Depression : Therapeutic Implications. / Lloyd, R. Brett; Nemeroff, Charles.

In: Current Topics in Medicinal Chemistry, Vol. 11, No. 6, 28.03.2011, p. 609-617.

Research output: Contribution to journalArticle

@article{9e0b3eac64524b9dbe2b5aff6bcb2a75,
title = "The role of Corticotropin-Releasing Hormone in the Pathophysiology of Depression: Therapeutic Implications",
abstract = "Stress responses have been posited to be a key component of mental health and disease by playing essential roles both in normal adaptive processes and maladaptive physiological responses that in part underlie the pathogenesis of certain subtypes of mood and anxiety disorders. Early research focused on delineating the function of the hypothalamicpituitary-adrenal (HPA) axis and subsequently examined its role in mediating the mammalian stress responses and its hyperactivity in depression. Much evidence now supports an important function of the biological mediators of this system in relation to not only depression, but also anxiety, substance abuse, and psychotic disorders, and implicates several components of this system as areas of intervention for novel pharmacotherapy. Perhaps the best studied central nervous system (CNS) component of this system is corticotropin-releasing factor (CRF), and considerable research has focused on its role in the HPA axis, as well in extrahypothalamic brain regions.",
keywords = "Corticotropin-releasing factor, depression, early life stress, hypothalamic-pituitary-adrenal axis",
author = "Lloyd, {R. Brett} and Charles Nemeroff",
year = "2011",
month = "3",
day = "28",
language = "English",
volume = "11",
pages = "609--617",
journal = "Current Topics in Medicinal Chemistry",
issn = "1568-0266",
publisher = "Bentham Science Publishers B.V.",
number = "6",

}

TY - JOUR

T1 - The role of Corticotropin-Releasing Hormone in the Pathophysiology of Depression

T2 - Therapeutic Implications

AU - Lloyd, R. Brett

AU - Nemeroff, Charles

PY - 2011/3/28

Y1 - 2011/3/28

N2 - Stress responses have been posited to be a key component of mental health and disease by playing essential roles both in normal adaptive processes and maladaptive physiological responses that in part underlie the pathogenesis of certain subtypes of mood and anxiety disorders. Early research focused on delineating the function of the hypothalamicpituitary-adrenal (HPA) axis and subsequently examined its role in mediating the mammalian stress responses and its hyperactivity in depression. Much evidence now supports an important function of the biological mediators of this system in relation to not only depression, but also anxiety, substance abuse, and psychotic disorders, and implicates several components of this system as areas of intervention for novel pharmacotherapy. Perhaps the best studied central nervous system (CNS) component of this system is corticotropin-releasing factor (CRF), and considerable research has focused on its role in the HPA axis, as well in extrahypothalamic brain regions.

AB - Stress responses have been posited to be a key component of mental health and disease by playing essential roles both in normal adaptive processes and maladaptive physiological responses that in part underlie the pathogenesis of certain subtypes of mood and anxiety disorders. Early research focused on delineating the function of the hypothalamicpituitary-adrenal (HPA) axis and subsequently examined its role in mediating the mammalian stress responses and its hyperactivity in depression. Much evidence now supports an important function of the biological mediators of this system in relation to not only depression, but also anxiety, substance abuse, and psychotic disorders, and implicates several components of this system as areas of intervention for novel pharmacotherapy. Perhaps the best studied central nervous system (CNS) component of this system is corticotropin-releasing factor (CRF), and considerable research has focused on its role in the HPA axis, as well in extrahypothalamic brain regions.

KW - Corticotropin-releasing factor

KW - depression

KW - early life stress

KW - hypothalamic-pituitary-adrenal axis

UR - http://www.scopus.com/inward/record.url?scp=79952948880&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79952948880&partnerID=8YFLogxK

M3 - Article

C2 - 21261589

AN - SCOPUS:79952948880

VL - 11

SP - 609

EP - 617

JO - Current Topics in Medicinal Chemistry

JF - Current Topics in Medicinal Chemistry

SN - 1568-0266

IS - 6

ER -