The role of complement in stroke therapy

Ricardo J Komotar, Grace H. Kim, Marc L. Otten, Benjamin Hassid, J. Mocco, Michael E. Sughrue, Robert M. Starke, William J. MacK, Andrew F. Ducruet, Maxwell B. Merkow, Matthew C. Garrett, E. Sander Connolly

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Cerebral ischemia and reperfusion initiate an inflammatory process which results in secondary neuronal damage. Immunomodulatory agents represent a promising means of salavaging viable tissue following stroke. The complement cascade is a potent mediator of inflammation which is activated following cerebral ischemia. Complement is deposited on apoptotic neurons which likely leads to injury in adjacent viable cells. Studies suggest that blocking the complement cascade during the early phases of infarct evolution may result in decreased penumbral tissue infarction and limit the extent of brain injury. Additionally, other elements of the complement cascade may play a critical role in cell survival. In this paper, we review the role of the complement cascade in neuronal damage following ischemic injury and emphasize possible therapeutic targets.

Original languageEnglish
Pages (from-to)23-33
Number of pages11
JournalAdvances in Experimental Medicine and Biology
Volume632
StatePublished - Dec 1 2008
Externally publishedYes

Fingerprint

Brain Ischemia
Stroke
Tissue
Inflammation Mediators
Wounds and Injuries
Brain Injuries
Infarction
Neurons
Reperfusion
Brain
Cell Survival
Cells
Therapeutics

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Komotar, R. J., Kim, G. H., Otten, M. L., Hassid, B., Mocco, J., Sughrue, M. E., ... Connolly, E. S. (2008). The role of complement in stroke therapy. Advances in Experimental Medicine and Biology, 632, 23-33.

The role of complement in stroke therapy. / Komotar, Ricardo J; Kim, Grace H.; Otten, Marc L.; Hassid, Benjamin; Mocco, J.; Sughrue, Michael E.; Starke, Robert M.; MacK, William J.; Ducruet, Andrew F.; Merkow, Maxwell B.; Garrett, Matthew C.; Connolly, E. Sander.

In: Advances in Experimental Medicine and Biology, Vol. 632, 01.12.2008, p. 23-33.

Research output: Contribution to journalArticle

Komotar, RJ, Kim, GH, Otten, ML, Hassid, B, Mocco, J, Sughrue, ME, Starke, RM, MacK, WJ, Ducruet, AF, Merkow, MB, Garrett, MC & Connolly, ES 2008, 'The role of complement in stroke therapy', Advances in Experimental Medicine and Biology, vol. 632, pp. 23-33.
Komotar RJ, Kim GH, Otten ML, Hassid B, Mocco J, Sughrue ME et al. The role of complement in stroke therapy. Advances in Experimental Medicine and Biology. 2008 Dec 1;632:23-33.
Komotar, Ricardo J ; Kim, Grace H. ; Otten, Marc L. ; Hassid, Benjamin ; Mocco, J. ; Sughrue, Michael E. ; Starke, Robert M. ; MacK, William J. ; Ducruet, Andrew F. ; Merkow, Maxwell B. ; Garrett, Matthew C. ; Connolly, E. Sander. / The role of complement in stroke therapy. In: Advances in Experimental Medicine and Biology. 2008 ; Vol. 632. pp. 23-33.
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