The role of chemokine receptor 9/chemokine ligand 25 signaling: From immune cells to cancer cells (Review)

Cong Wang, Zhenghuan Liu, Zhihui Xu, Xian Wu, Dongyang Zhang, Ziqi Zhang, Jianqin Wei

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Chemokine ligand 25 (CCL25) and chemokine receptor 9 (CCR9) are important regulators of migration, proliferation and apoptosis in leukocytes and cancer cells. Blocking of the CCR9/CCL25 signal has been demonstrated to be a potential novel cancer therapy. Research into CCR9 and CCL25 has revealed their associated upstream and downstream signaling pathways; CCR9 is regulated by several immunological factors, including NOTCH, interleukin 2, interleukin 4 and retinoic acid. NOTCH in particular, has been revealed to be a crucial upstream regulator of CCR9. Furthermore, proteins including matrix metalloproteinases, P-glycoprotein, Ezrin/Radixin/Moesin and Livin are regulated via phosphatidylinositol-3 kinase/ protein kinase B, which are in turn stimulated by CCR9/CCL25. This is a review of the current literature on the functions and signaling pathways of CCR9/CCL25.

Original languageEnglish (US)
Pages (from-to)2071-2077
Number of pages7
JournalOncology Letters
Volume16
Issue number2
DOIs
StatePublished - Aug 2018

Keywords

  • Chemokine receptor 9
  • Immune system
  • Tumor suppressor genes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'The role of chemokine receptor 9/chemokine ligand 25 signaling: From immune cells to cancer cells (Review)'. Together they form a unique fingerprint.

  • Cite this