The role of central dopaminergic systems in the behavioral effects of H-Phe-Ile-Tyr-His-Ser-Tyr-Lys-OH

L. Vécsei; G. Telegdy; I. Bollók; A. V. Schally

doi:10.1016/0143-4179(85)90089-7

The role of central dopaminergic systems in the behavioral effects of H-Phe-Ile-Tyr-His-Ser-Tyr-Lys-OH

L. Vécsei, G. Telegdy, I. Bollók, A. V. Schally

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

In the present study the role of the central dopaminergic systems in the behavioral action of H-Phe-Ile-Tyr-His-Ser-Tyr-Lys-OH was investigated. The heptapeptide inhibited the extinction of active avoidance behavior if the treatment was performed intracerebroventricularly (icv) in a dose of 1 μg, but was ineffective in a dose of 0.1 μg. If the peptide was injected into the nucleus accumbens septi (NAS) in a dose of 1 μg, 0.1 μg or 0.01 μg it inhibited the extinction, but in the latter dose its effect was only a short one. H-Phe-Ile-Tyr-His-Ser-Tyr-Lys-OH in a dose of 1 μg, 10 μg or 20 μg (icv) did not influence the turning activity of unilateral substantia nigra (USN)-lesioned animals. These results suggest that the NAS plays an important role in the behavioral action of H-Phe-Ile-Tyr-His-Ser-Tyr-Lys-OH and the heptapeptide has no direct dopamine receptor stimulatory or dopamine-releasing effect in the striatum.

Original language	English (US)
Pages (from-to)	183-190
Number of pages	8
Journal	Neuropeptides
Volume	6
Issue number	3
DOIs	https://doi.org/10.1016/0143-4179(85)90089-7
State	Published - Jun 1985
Externally published	Yes

ASJC Scopus subject areas

Endocrinology
Neurology
Endocrine and Autonomic Systems
Cellular and Molecular Neuroscience

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10.1016/0143-4179(85)90089-7

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title = "The role of central dopaminergic systems in the behavioral effects of H-Phe-Ile-Tyr-His-Ser-Tyr-Lys-OH",

abstract = "In the present study the role of the central dopaminergic systems in the behavioral action of H-Phe-Ile-Tyr-His-Ser-Tyr-Lys-OH was investigated. The heptapeptide inhibited the extinction of active avoidance behavior if the treatment was performed intracerebroventricularly (icv) in a dose of 1 μg, but was ineffective in a dose of 0.1 μg. If the peptide was injected into the nucleus accumbens septi (NAS) in a dose of 1 μg, 0.1 μg or 0.01 μg it inhibited the extinction, but in the latter dose its effect was only a short one. H-Phe-Ile-Tyr-His-Ser-Tyr-Lys-OH in a dose of 1 μg, 10 μg or 20 μg (icv) did not influence the turning activity of unilateral substantia nigra (USN)-lesioned animals. These results suggest that the NAS plays an important role in the behavioral action of H-Phe-Ile-Tyr-His-Ser-Tyr-Lys-OH and the heptapeptide has no direct dopamine receptor stimulatory or dopamine-releasing effect in the striatum.",

author = "L. V{\'e}csei and G. Telegdy and I. Boll{\'o}k and Schally, {A. V.}",

note = "Funding Information: This work was supported by the Scientific Research Council I Hungarian Ministry of Health (16/4-10/502/T). The authors extend grateful appreciation to Miss Eva za for skilled technical assistance, and Dr. I<. Boda statistical evaluation. H-Phe-Ile-Tyr-His-Ser-Tyr-Lys-OH was synthetized by Dr. D.H. Coy (New Orleans,",

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AU - Schally, A. V.

N1 - Funding Information: This work was supported by the Scientific Research Council I Hungarian Ministry of Health (16/4-10/502/T). The authors extend grateful appreciation to Miss Eva za for skilled technical assistance, and Dr. I<. Boda statistical evaluation. H-Phe-Ile-Tyr-His-Ser-Tyr-Lys-OH was synthetized by Dr. D.H. Coy (New Orleans,

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The role of central dopaminergic systems in the behavioral effects of H-Phe-Ile-Tyr-His-Ser-Tyr-Lys-OH

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