Abstract
In the present study the role of the central dopaminergic systems in the behavioral action of H-Phe-Ile-Tyr-His-Ser-Tyr-Lys-OH was investigated. The heptapeptide inhibited the extinction of active avoidance behavior if the treatment was performed intracerebroventricularly (icv) in a dose of 1 μg, but was ineffective in a dose of 0.1 μg. If the peptide was injected into the nucleus accumbens septi (NAS) in a dose of 1 μg, 0.1 μg or 0.01 μg it inhibited the extinction, but in the latter dose its effect was only a short one. H-Phe-Ile-Tyr-His-Ser-Tyr-Lys-OH in a dose of 1 μg, 10 μg or 20 μg (icv) did not influence the turning activity of unilateral substantia nigra (USN)-lesioned animals. These results suggest that the NAS plays an important role in the behavioral action of H-Phe-Ile-Tyr-His-Ser-Tyr-Lys-OH and the heptapeptide has no direct dopamine receptor stimulatory or dopamine-releasing effect in the striatum.
Original language | English (US) |
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Pages (from-to) | 183-190 |
Number of pages | 8 |
Journal | Neuropeptides |
Volume | 6 |
Issue number | 3 |
DOIs | |
State | Published - Jun 1985 |
Externally published | Yes |
ASJC Scopus subject areas
- Endocrinology
- Neurology
- Endocrine and Autonomic Systems
- Cellular and Molecular Neuroscience