The role of cell adhesion molecule L1 in axonal extension, growth cone motility, and signal transduction

Susan M. Burden-Gulley, Maryanne Pendergast, Vance Lemmon

Research output: Contribution to journalArticle

73 Scopus citations

Abstract

Axonal pathfinding is a complex process dependent on cell-cell and cell-matrix interactions. L1 is a cell adhesion molecule that is abundant in the nervous system and that is concentrated on axons. As a culture substrate, L1 is a potent promoter of neurite outgrowth and elicits specific growth cone behavior. It interacts with the actin cytoskeleton via an ankyrin linkage and promotes specific distribution of F-actin within the growth cone. In addition, L1 has been implicated in signal transduction. For example, L1 is associated with kinases, L1-L1 binding regulates second messenger systems, and mutations in the L1 gene in humans result in abnormalities in the development of the corticospinal tract and corpus callosum. In this short review, recent advances in understanding the way in which L1 regulates growth cone behavior will be discussed.

Original languageEnglish (US)
Pages (from-to)415-422
Number of pages8
JournalCell and Tissue Research
Volume290
Issue number2
DOIs
StatePublished - Nov 13 1997
Externally publishedYes

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Keywords

  • Axonal extension
  • Cell adhesion molecule L1
  • Cytoskeleton
  • Growth cones
  • Signal transduction

ASJC Scopus subject areas

  • Anatomy
  • Clinical Biochemistry
  • Cell Biology

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