The role of canine superficial ventricular muscle fibers in endocardial impulse distribution

Robert J Myerburg, H. Gelband, K. Nilsson, Agustin Castellanos, Azorides R Morales, A. L. Bassett

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Thin sections of canine right and left ventricular endocardium and myocardium were studied in a tissue bath to compare conduction properties of intraventricular specialized conducting tissue [Purkinje fibers (PF)], the superficial layers of subendocardial ventricular muscle (SVM), and the deeper ventricular muscle (DVM) below this level. The study was carried out because of observations that some areas of the endocardium, which are devoid of either specialized conducting tissue or of PF-VM junctions between specialized conducting tissue and ventricular muscle, conduct relatively rapidly, favoring specific orientations of propagation. Preparations containing PF, SVM, and DVM, were studied electrophysiologically and histologically. A technique of stripping limited areas of endocardium was used to expose DVM in order to determine its intrisinc calculated conduction velocity. In 12 preparations, the average calculated conduction velocity in PF was 1.62 m/sec, and the average in DVM was 0.26 m/sec. The SVM conduction velocity was intermediate between the two, averaging 0.98 m/sec when propagation was parallel to SVM fiber orientation. Conduction velocity transverse to SVM fiber orientation was not significantly different from DVM conduction velocity. Histologically, the most superficial layers of VM were oriented uniformly in the direction of rapid subendocardial conduction, in contrast to DVM fibers in which orientation varied. It is concluded that the geometric arrangement of SVM fibers may provide a means for rapid subendocardial conduction and impulse distribution at a conduction velocity intermediate between PF and DVM in areas devoid of specialized conducting tissue.

Original languageEnglish
Pages (from-to)27-35
Number of pages9
JournalCirculation Research
Volume42
Issue number1
StatePublished - Jul 9 1978

Fingerprint

Canidae
Muscles
Purkinje Fibers
Endocardium
Baths
Myocardium

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Myerburg, R. J., Gelband, H., Nilsson, K., Castellanos, A., Morales, A. R., & Bassett, A. L. (1978). The role of canine superficial ventricular muscle fibers in endocardial impulse distribution. Circulation Research, 42(1), 27-35.

The role of canine superficial ventricular muscle fibers in endocardial impulse distribution. / Myerburg, Robert J; Gelband, H.; Nilsson, K.; Castellanos, Agustin; Morales, Azorides R; Bassett, A. L.

In: Circulation Research, Vol. 42, No. 1, 09.07.1978, p. 27-35.

Research output: Contribution to journalArticle

Myerburg, RJ, Gelband, H, Nilsson, K, Castellanos, A, Morales, AR & Bassett, AL 1978, 'The role of canine superficial ventricular muscle fibers in endocardial impulse distribution', Circulation Research, vol. 42, no. 1, pp. 27-35.
Myerburg RJ, Gelband H, Nilsson K, Castellanos A, Morales AR, Bassett AL. The role of canine superficial ventricular muscle fibers in endocardial impulse distribution. Circulation Research. 1978 Jul 9;42(1):27-35.
Myerburg, Robert J ; Gelband, H. ; Nilsson, K. ; Castellanos, Agustin ; Morales, Azorides R ; Bassett, A. L. / The role of canine superficial ventricular muscle fibers in endocardial impulse distribution. In: Circulation Research. 1978 ; Vol. 42, No. 1. pp. 27-35.
@article{84382cbb0d5b42408a96a65c244116f3,
title = "The role of canine superficial ventricular muscle fibers in endocardial impulse distribution",
abstract = "Thin sections of canine right and left ventricular endocardium and myocardium were studied in a tissue bath to compare conduction properties of intraventricular specialized conducting tissue [Purkinje fibers (PF)], the superficial layers of subendocardial ventricular muscle (SVM), and the deeper ventricular muscle (DVM) below this level. The study was carried out because of observations that some areas of the endocardium, which are devoid of either specialized conducting tissue or of PF-VM junctions between specialized conducting tissue and ventricular muscle, conduct relatively rapidly, favoring specific orientations of propagation. Preparations containing PF, SVM, and DVM, were studied electrophysiologically and histologically. A technique of stripping limited areas of endocardium was used to expose DVM in order to determine its intrisinc calculated conduction velocity. In 12 preparations, the average calculated conduction velocity in PF was 1.62 m/sec, and the average in DVM was 0.26 m/sec. The SVM conduction velocity was intermediate between the two, averaging 0.98 m/sec when propagation was parallel to SVM fiber orientation. Conduction velocity transverse to SVM fiber orientation was not significantly different from DVM conduction velocity. Histologically, the most superficial layers of VM were oriented uniformly in the direction of rapid subendocardial conduction, in contrast to DVM fibers in which orientation varied. It is concluded that the geometric arrangement of SVM fibers may provide a means for rapid subendocardial conduction and impulse distribution at a conduction velocity intermediate between PF and DVM in areas devoid of specialized conducting tissue.",
author = "Myerburg, {Robert J} and H. Gelband and K. Nilsson and Agustin Castellanos and Morales, {Azorides R} and Bassett, {A. L.}",
year = "1978",
month = "7",
day = "9",
language = "English",
volume = "42",
pages = "27--35",
journal = "Circulation Research",
issn = "0009-7330",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

TY - JOUR

T1 - The role of canine superficial ventricular muscle fibers in endocardial impulse distribution

AU - Myerburg, Robert J

AU - Gelband, H.

AU - Nilsson, K.

AU - Castellanos, Agustin

AU - Morales, Azorides R

AU - Bassett, A. L.

PY - 1978/7/9

Y1 - 1978/7/9

N2 - Thin sections of canine right and left ventricular endocardium and myocardium were studied in a tissue bath to compare conduction properties of intraventricular specialized conducting tissue [Purkinje fibers (PF)], the superficial layers of subendocardial ventricular muscle (SVM), and the deeper ventricular muscle (DVM) below this level. The study was carried out because of observations that some areas of the endocardium, which are devoid of either specialized conducting tissue or of PF-VM junctions between specialized conducting tissue and ventricular muscle, conduct relatively rapidly, favoring specific orientations of propagation. Preparations containing PF, SVM, and DVM, were studied electrophysiologically and histologically. A technique of stripping limited areas of endocardium was used to expose DVM in order to determine its intrisinc calculated conduction velocity. In 12 preparations, the average calculated conduction velocity in PF was 1.62 m/sec, and the average in DVM was 0.26 m/sec. The SVM conduction velocity was intermediate between the two, averaging 0.98 m/sec when propagation was parallel to SVM fiber orientation. Conduction velocity transverse to SVM fiber orientation was not significantly different from DVM conduction velocity. Histologically, the most superficial layers of VM were oriented uniformly in the direction of rapid subendocardial conduction, in contrast to DVM fibers in which orientation varied. It is concluded that the geometric arrangement of SVM fibers may provide a means for rapid subendocardial conduction and impulse distribution at a conduction velocity intermediate between PF and DVM in areas devoid of specialized conducting tissue.

AB - Thin sections of canine right and left ventricular endocardium and myocardium were studied in a tissue bath to compare conduction properties of intraventricular specialized conducting tissue [Purkinje fibers (PF)], the superficial layers of subendocardial ventricular muscle (SVM), and the deeper ventricular muscle (DVM) below this level. The study was carried out because of observations that some areas of the endocardium, which are devoid of either specialized conducting tissue or of PF-VM junctions between specialized conducting tissue and ventricular muscle, conduct relatively rapidly, favoring specific orientations of propagation. Preparations containing PF, SVM, and DVM, were studied electrophysiologically and histologically. A technique of stripping limited areas of endocardium was used to expose DVM in order to determine its intrisinc calculated conduction velocity. In 12 preparations, the average calculated conduction velocity in PF was 1.62 m/sec, and the average in DVM was 0.26 m/sec. The SVM conduction velocity was intermediate between the two, averaging 0.98 m/sec when propagation was parallel to SVM fiber orientation. Conduction velocity transverse to SVM fiber orientation was not significantly different from DVM conduction velocity. Histologically, the most superficial layers of VM were oriented uniformly in the direction of rapid subendocardial conduction, in contrast to DVM fibers in which orientation varied. It is concluded that the geometric arrangement of SVM fibers may provide a means for rapid subendocardial conduction and impulse distribution at a conduction velocity intermediate between PF and DVM in areas devoid of specialized conducting tissue.

UR - http://www.scopus.com/inward/record.url?scp=0017873548&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017873548&partnerID=8YFLogxK

M3 - Article

VL - 42

SP - 27

EP - 35

JO - Circulation Research

JF - Circulation Research

SN - 0009-7330

IS - 1

ER -