The role of C9 in complement-mediated killing of Neisseria

G. R. Harriman, A. F. Esser, E. R. Podack, A. C. Wunderlich, A. I. Braude, T. F. Lint, J. G. Curd

Research output: Contribution to journalArticle

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Abstract

During the routine examination of a healthy 31-yr-old woman, we found an incomplete deficiency of the 9th component of complement (C9). By hemolytic assay her serum C9 activity was 10 to 15% of normal. Limited family studies suggested that she inherited the deficiency as an autosomal codominant trait. She had no history of unusual or severe infections. When tested for bactericidal activity against serum-sensitive Neisseria gonorrhoeae and N. meningitidis, her serum reacted comparably to normal serum. Normal serum depleted immunochemically of C9 and sera from congenitally C9-deficient patients were also bactericidal against serum-sensitive Neisseria but required 120 min to kill the same numbers of gonococci that intact serum killed within 30 min. In the electron microscope, N. gonorrhoeae incubated with C9-depleted serum were fragmented but lacked the typical C lesions. Therefore, serum lacking C9 can kill serum-sensitive Neisseria, unlike sera deficient in the other terminal C components.

Original languageEnglish
Pages (from-to)2386-2390
Number of pages5
JournalJournal of Immunology
Volume127
Issue number6
StatePublished - Dec 1 1981
Externally publishedYes

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Complement C9
Neisseria
Serum
Neisseria gonorrhoeae

ASJC Scopus subject areas

  • Immunology

Cite this

Harriman, G. R., Esser, A. F., Podack, E. R., Wunderlich, A. C., Braude, A. I., Lint, T. F., & Curd, J. G. (1981). The role of C9 in complement-mediated killing of Neisseria. Journal of Immunology, 127(6), 2386-2390.

The role of C9 in complement-mediated killing of Neisseria. / Harriman, G. R.; Esser, A. F.; Podack, E. R.; Wunderlich, A. C.; Braude, A. I.; Lint, T. F.; Curd, J. G.

In: Journal of Immunology, Vol. 127, No. 6, 01.12.1981, p. 2386-2390.

Research output: Contribution to journalArticle

Harriman, GR, Esser, AF, Podack, ER, Wunderlich, AC, Braude, AI, Lint, TF & Curd, JG 1981, 'The role of C9 in complement-mediated killing of Neisseria', Journal of Immunology, vol. 127, no. 6, pp. 2386-2390.
Harriman GR, Esser AF, Podack ER, Wunderlich AC, Braude AI, Lint TF et al. The role of C9 in complement-mediated killing of Neisseria. Journal of Immunology. 1981 Dec 1;127(6):2386-2390.
Harriman, G. R. ; Esser, A. F. ; Podack, E. R. ; Wunderlich, A. C. ; Braude, A. I. ; Lint, T. F. ; Curd, J. G. / The role of C9 in complement-mediated killing of Neisseria. In: Journal of Immunology. 1981 ; Vol. 127, No. 6. pp. 2386-2390.
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