The role of angiotensin II receptor-1 blockade in the hypoxic pulmonary vasoconstriction response in newborn piglets

José Simon Camelo, Dorothy Hehre, Carlos Devia, Sílvia Helena Henriques Camelo, Eduardo Bancalari, Cleide Suguihara

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Background: Angiotensin-converting enzyme activity is increased in newborn infants with respiratory distress syndrome and in animals with alveolar hypoxia. Objective: To test whether angiotensin II (Ang II) mediates the pulmonary vasoconstriction induced by acute hypoxia in newborn piglets. Methods: Eight unanesthetized chronically instrumented newborn piglets (mean ± SEM; age 6.6 ± 0.6 days; weight 2,181 ± 174 g) were randomly assigned to receive a saline solution or the Ang II type 1 receptor (AT1) antagonist, losartan, in a crossover study design, with an interval of at least 48 h between the first and second study. Pulmonary artery (Ppa), wedge, systemic arterial (Psa) and right atrial pressures, cardiac output (CO), pulmonary (PVR) and systemic (SVR) vascular resistances, and arterial blood gases were obtained in room air, before and during the saline or losartan infusion (6 mg/kg followed by 3 mg/kg/h), and during 6 h of hypoxia (FiO2 = 0.11) and saline or losartan infusion. Data were analyzed by repeated measures analysis of variance. Results: The pulmonary vasoconstriction induced by acute hypoxia was significantly attenuated during losartan infusion, while Psa, SVR, CO, pH, PaCO2, PaO2 and base excess did not differ between groups. During room air, Ppa, PVR, Psa, SVR and CO values were not modified by saline or losartan infusion. Conclusion: These data suggest that the pulmonary vasoconstriction induced by acute hypoxia in newborn piglets is partially mediated by Ang II, acting via AT1.

Original languageEnglish (US)
Pages (from-to)263-268
Number of pages6
JournalNeonatology
Volume93
Issue number4
DOIs
StatePublished - Jun 1 2008

Keywords

  • Angiotensin II
  • Hypoxemia
  • Newborn piglets
  • Pulmonary arterial hypertension
  • Receptor antagonist, angiotensin II

ASJC Scopus subject areas

  • Developmental Biology
  • Pediatrics, Perinatology, and Child Health

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